What kind of difficulties were faced in animal domestication?

Answer 1

When a 'wild' animal is domesticated, even from birth, when they reach puberty, they, like teenagers, tend to become headstrong and many will revert to their natural stage, even when they have become humanized. Many males are more dangerous when they become stronger and are not neutered. (Not that I am suggesting THAT.) It may take many generations to truly domesticate a species, like dogs and cats. If the animal you have in mind, grows larger than you, like a chimp, a bull, an elephant or a tiger, you are never really safe, because they have their moods, like a human does, and that single bad mood can hurt or even kill you.