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Mainly to the Caribbean and South America (Brazil and Columbia). Very few were sent to Central America and Mexico.
they was searching for a waterway through or around north america, or a northwest passage to asia
They weren't "sent" by anyone. The pilgrims left for America in order to achieve religious freedom. (I am assuming that you are referring to the pilgrims that settled the Plymouth Colony)
Queen Isabella did not in fact explore anywhere. she sent explorers to go. these explorers mostly went to the new world.
the middle passage is one part of the triangular trade. the middle passage was the boat ride slaves were on to get to the place they were being delivered to. the triangular trade route was the process of the slaves being delivered from Africa to America,America sends sugar and other raw materials to Europe, and Europe sent textiles and guns to Africa. hope that helps (: