It killed many many people.
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Yes, the Bubonic plague whad hit an epidemic before 1564 and was winding down by 1616.
In Venice they moved all the sick people to an island and allowed them to die. Over 5,000 a day died in Venice at the height of the plague.
The Bubonic plague (aka) The black Death killed millions where WW1 only killed a couple hundred thousand.
An Internet search of the question found a possible answer could be that once the plague ended, it never returned to Europe.Without seeing the multiple choices that were offered in the test, you could answer with almost anything.==========================C. Respect for the Mongols
World War I and II, and the atomic bomb were the big events of the twentieth century. The two events that may have affected the course of the history of the world were the bubonic plague and European colonization of everywhere outside of Europe.