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"Bio" is a prefix that refers to biological matter, such as flesh and leaves, and anything that lives. "Shock" refers to a state when something happens that was unprepared for, usually the result of a sudden event rather than a passive one. Put these together and you get "Bioshock" a word that describes A sudden spike in stimulus in a living being. The plasmids you procure and use throughout Bioshock rewrite your genetic code, something that nature never intends to happen hence the name "Bioshock".

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Q: Why is Bioshock called Bioshock?
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Is bioshock 2 have to do anything with bioshock 3?

No. Bioshock 2 is set in the underwater city of Rapture. Bioshock Infinite is set in a flying city called Columbia, and it is set a few decades before Rapture was built.


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