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The brain is suspended in the skull by liquid. An impact to the skull hard enough to cause the brain to slosh through the liquid and hit the interior of the skull will cause unconsciousness. The amount of time that a person spends unconscious is determined by how hard the brain hits the skull. For the most part, it's not a hit to the jaw specifically that causes a KO. A shot to any part of the face that is hard enough to rattle the brain will do. However, the jaw is the most muscular part of the face; therefore, it is most favorable because a large amount of blunt force is needed to KO someone. The amount of muscle in the jaw means more cushion for your fist against the bone. This means more impact can be placed into the punch.

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Q: Why does a punch on the jaw make you unconscious?
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