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"scrub (v.) "rub hard," c.1300, perhaps from M.Du. or M.L.G. schrubben "to scrub," or from an unrecorded O.E. cognate, or from a Scand. source (cf. Dan. skrubbe "to scrub"), probably ult. from some cognate of shrub, used as a cleaning tool (cf. the evolution of broom, brush). Meaning "to cancel" is attested from 1828 (popularized during World War II with ref. to flights), probably from notion of "to rub out, erase." The noun is recorded from 1621."

Source: Online Etymology Dictionary

A "Scrub" could also be used as slang to insult someone saying they are inferrior or unimportant.

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Q: Is 'scrub' a combination of 'scratch' and 'rub'?
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