How toxic is indoxacarb 0.05 percent of 0.14 oz to a 40 lb. dog and what are the symptoms of poisoning?

Answer 1

# Animal Data

DuPont Steward Insecticide

Oral LD50: 3619 mg/kg in male rats

Oral LD50: 751 mg/kg in female rats (Slight toxicity)

Dermal LD50: >5000 mg/kg in rats (Slight toxicity)

Inhalation 4 hour LC50: >2.7 mg/L in rats (Very low toxicity)

DuPont Steward Insecticide is a slight to mild skin irritant, and is a skin sensitizer, but is not an eye irritant in animals.

DuPont Steward Insecticide in high single oral doses caused gait abnormalities, incoordination, hypoactivity, convulsions, tremors, hypothermia, hair loss, labored respiration, discharge, and vocalization in rats.

Single oral dosing studies with DPX-MP062 (containing 75% Indoxacarb, active ingredient) to assess potential neurotoxicity were conducted in male and female rats. The NOEL for neurotoxicity was 100 mg/kg for male rats and 12.5 mg/kg for female rats.

Repeated oral dosing with DPX-MP062 (containing 75% Indoxacarb, active ingredient) caused mild hemolytic anemia and reduced body weight gain in male and female rats; additionally, female rats experienced weakness and incoordination while male rats exhibited some changes in clinical chemical measurements. The No-Observed-Effect-Level (NOEL) in a 90-day repeated oral dosing study was 100 ppm for male rats and 25 ppm for female rats.

Single inhalation exposure to DuPont Steward Insecticide in rats caused lung noise immediately following exposure; no clinical signs were noted during the 14-day recovery period.

Based on animal data from DPX-JW062 (containing 50% Indoxacarb, active ingredient), the following chronic effects may occur in animals with Indoxacarb.

Ingestion of DPX-JW062 by dogs for one-year caused hemolytic anemia with secondary histopathological changes and decreased body weights. The NOEL for both male and female dogs was 40 ppm. Effects in male and female rats that were fed DPX-JW062 in their diets for two-years include decreased body weight, in addition femalesalso had some hemolysis. The NOEL for the two-year rat feeding study was 60 ppm for male rats and 40 ppm for female rats. Male and female mice fed DPX-JW062 for eighteen months had decreased body weight, in addition females showed signsof neurotoxicity, some mortality, and a few incidences of histopathologic changes in the brain (probably secondary to seizures). The NOEL for the eighteen month mouse feeding study was 20 ppm in male and female mice.

Tests have shown that DPX-MP062 (containing 75% Indoxacarb, active ingredient) does not cause genetic damage in bacterial or mammalian cell cultures or in animals.

Based on animal data from DPX-JW062 (containing 50% Indoxacarb, active ingredient) Indoxacarb is not considered a carcinogenic or reproductive hazard.

Indoxacarb is not considered a developmental hazard. The maternal and developmental NOEL was 2.0 mg/kg.