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The Shawnee tribe killed the most white settlers.

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Q: What tribe killed the most White Settlers?
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What is the impact of the blackfeet and settlers?

The Blackfeet tribe were the most aggressive and noncooperation tribe toward white settlers. Many settlers tried to avoid the Blackfeet tribe, or the confrontation would result in deadly conflict.


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The fate of the first settlers of Roanoke Island, known as the Lost Colony, remains a mystery. They disappeared sometime between 1587 and 1590. There are various theories, including being killed by Native Americans or integrating into local tribes.