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Operation Sea-Spray was a U.S. Navy secret operation / experiment that used burst balloons to disperse the bacterium Serratia marcescens over the city of San Francisco on Sept. 26-27, 1950.
Until that time, S. marcescens was thought to be non-pathogenic (incapable of causing disease), and had been used as a simulant in biological warfare tests. Until Sea-Spray, there wasn't any indication that it was dangerous or infectious. That was proven to be wrong after the dispersal test.
Within a few days of the dispersal, several serious and rare cases of urinary tract infections evolved (with one fatality), and there was a marked increase in the number of pneumonia cases in the area as well.
Since 1950, the S. marcescens has grown and become more resistant to antibiotics.
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