Florence, Milan, Venice, and Genoa Florence, Milan, Venice, and Genoa
The most popular are the tourist destinations such as Rome, Venice, Milan, Florence, Turin, if you could call it a city also the island of Capri. It is dependent on what you are seeking and perhaps the questions requires more refinement.
Although it is in Germany, Munich is considered Italy's northern most city. This is because of it's proximity to Italy.
There are several cities in northern Italy. Some of these include Venice, Florence, Milan, Turin, Trento, Aosta, as well as Genoa.
The city most often cited as the birthplace of the Renaissance is Florence.
Rome and Milan are the 2 largest cities is Italy.
Milan-Turin-Genoa
Genoa, Venice, Otranto, Ancona, Civitavecchia
Genoa Venice or rome
The major TRADE Cities were: Rome, Florence, Venice, Bologna, Naples and Milan.
Rome. Florence and Venice especially grew rich from trade, and as did Genoa to a lesser extent. Rome, though important through most of the Middle Ages and Renaissance, was not a trade city.
Milan is the wealthiest city in Italy.