I-65 SOUTH (from INDIANA).
The quickest route in regards to the shortest number of miles driven can be found on Mapquest.
From the south side of Central Park in NYC to "Five Points" in the center of downtown Atlanta is approximately 868 miles by the quickest road route; or approximately 847 miles by the shortest distance road route.
By plane. If you are driving, I5 would be the quickest, most direct route.
The A1 motorway.
maps.google.com
The quickest route is 1,958 miles.
The quickest driving route to Eliat from Jerusalem is 308 km
The shortest and the quickest route is I-85 N.
The shortest route is I-75 N.
Take I-80 EAST to Chicago.
The quickest route is about 493 miles. The longest is about 524 miles.