It is called Kaaba; the oldest God house on earth.
It is located in Makkah (or Mecca) in Saudi Arabia.
Jerusalem is a Holy city in Judaism, Christianity & Islam.
== Mecca.
Bethlehem, Calvary and Jerusalem are holy to Christians. The temple mount which is the base where the temple of Solomon used to stand is holy to Jewish people and for some reason the same spot is called holy by muslims because muslims built a mosque where the temple of Solomon used to be.
The Ka'aba is the first house for the worship of the One God built on Earth. So says the Qur'an. It was built, by Abraham and his son Ishmael, even before the Temple in Jerusalem. It was dedicated, by Abraham, as a place for pilgrimage. That is the significance of the Ka'aba to Muslims.
ANSWERAl-Aqsa, because it was built by a Prophet and Allah had taken Prophet Muhammad in a night to that mosque ( according to Quran) and he performed prayer
This pilgrimage is called the Hajj.
Israel/Palestine.
Israel/Palestine
The Muslims have the Dome of the Rock Shrine and the Al-Aqsa Mosque which form a single holy site together.
Is The Dome of the Rock a religious holy site for Christians,Muslims ,or Jews
It is called the Ka'ba (Kaaba) meaning the CUBE, where Muslims worship the one and only God named Allah. It was built by Abraham (Ibrahim) and his son Isma'eel (Peace and blessings be on them both). It is the required site for Muslims to pilgramage (The five pillars of Islam).
The holy site of Islam is located in Mecca, Saudi Arabia. Specifically, the Kaaba is located there (it's a giant black cube). The Kaaba is the most sacred and holy site in Islam. When Muslims pray, wherever they are on the globe, they pray in a certain direction so that way they are facing the Kaaba. They once faced Al-Aqsa (another holy site in Islam) Jerusalem as the direction of prayer.