Crab Orchard, TN, but I'd stop at Crossville.
Indiana
A halfway point between Crossville, TN and Fayetteville, NC (depending on your route) is Vein Mountain, NC.
The halfway point between Texarkana, TX and Yorktown, VA falls in or around Crossville, TN.
Eureka Center, Wisconsin is the halfway point.
It's about 70 miles from Knoxville to Crossville, going via Interstate 40. The closest city to a halfway point along that route is Kingston, which is 36 miles from Knoxville and about 35.5 miles from Crossville.
The halfway point between Wisconsin (WI) and Vermont (VT) is Pepper Pike, Ohio.
The halfway point between Evensville Tennesee and Knoxville Tennesee is Dogwood Shores Tennessee.
The halfway point between Memphis, Tennessee and Louisville, Kentucky is Pegram, Tennessee.
There is 610 miles between Milwaukee, Wisconsin, and Toronto, Canada. The halfway point between these two cities is Lansing, Michigan.
somewhere in Wisconsin
Manchester, TN