It depends on what you define "Middle America" as. If you define "Middle America" as the middle of the United States of America, then Chicago, Illinois would be the largest city with a population of 2.7 million people. If "Middle America" is the middle of the North American continent, then the twin cities of Minneapolis and St. Paul would be the largest city in that case (with a joint population of 3.28 million).
It is not the oldest in the Americas, but is the largest. Its name is Mexico City.
tenochtitlan
Mexico City
Mexico City is the largest in the Americas and third largest in the world, behind Tokyo and Seoul.
tenochtitlan
yes
Los Angeles is America's 2nd largest city after New York City.
Mexico City
The largest city in the southern hemisphere is São Paulo, Brazil. With a population of over 12 million people, São Paulo is not only the largest city in the southern hemisphere but also the largest city in the Americas.
Cairo
The largest city in the Middle East is Istanbul, Turkey. Wicked common mistake, Istanbul geographically is part of Europe, and Tehran is the current largest in the middle east Istanbul Does not belongs to Middle easf it, Turkey is half in Europe and half in Asia. By any mean Tehran is the larget city in Middle east
Mexico City is the largest city in the Americas. New York is the largest city in the US.