It is 586 miles according to Google Maps.
Pittsburgh is approximately 20 minutes from Mars Pennsylvania.
239 miles
Elkin, NC
It is 449.24 miles according to MapQuest.
About 8 and a half hours.
If you're going to Niagara Falls on the Buffalo, NY, side, the midpoint is going to be somewhere in the neighborhood of Washington, PA; not as far as Pittsburgh.
Consider Pittsburgh, PA.
$6.00 for a 2-axle car.
437 miles
240 miles
It will take approximately 8 hours and 48 minutes