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  1. Take I-77 SOUTH from Charlotte to I-26 EAST to CHARLESTON (TO I-95) at END I-77 near Columbia, South Carolina.
  2. Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.
  3. Take I-95 SOUTH to I-10 WEST via I-295 SOUTH to bypass JACKSONVILLE (EXIT 362B off I-95 in Florida to get onto I-295 SOUTH ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).
  4. Take I-10 WEST to U.S. 231 to COTTONDALE and PANAMA CITY at EXIT 130; turn left off the exit ramp to get onto U.S. 231 SOUTH to PANAMA CITY.
  5. Take U.S. 231 SOUTH to PANAMA CITY.
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13y ago
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13y ago

642 MILES ACCORDING TO OUR FRIENDS AT Google MAPS

why don't you go to map quest your self if you are traveling that far don't you think you would know the mileage?

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13y ago

It is 393.73 miles according to MapQuest.

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Q: How far away is Panama City FL from Tampa FL?
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