Do you need shots to go to Mazatlan?

Answer 1

If you are feeling especially vulnerable, you should look after anti-malarial medications, hepatitis A & B as well as typhoid fever vaccination.

However, what you should really care about is not drinking tap water, which more often than not will give you diarrhea (also known as Montezuma's Revenge). So, stay with purified/bottled water and avoid ice on your drinks. If you ever feel sick, pay a visit to the hotel doctor, who will provide meds to counter bacteria present in the water.