Best Driving route from jacksonville to St. Louis?

Answer 1

1. Take I-10 WEST to I-75 NORTH to VALDOSTA at EXIT 296B.
2. Take I-75 NORTH through Florida and Georgia to I-24 WEST to CHATTANOOGA and Nashville at EXIT 2 in Tennessee. On this stretch, you will bypass Macon, Georgia by taking I-475 NORTH (EXIT 156 off I-75) and you will also bypass Atlanta, Georgia by taking I-285 WEST BYPASS (EXIT 238B off I-75 and then EXIT 20 off I-285 to get back onto I-75 NORTH).
3. Take I-24 WEST through Tennessee (through Nashville) and Kentucky to I-57 NORTH to CHICAGO at EXIT 44B in Illinois.
4. Take I-57 NORTH to I-64 WEST to St. Louis at EXIT 96.
5. Continue on I-64 WEST to ST. LOUIS.

Answer 2

1. Take I-64 EAST to I-57 SOUTH.
2. Continue on I-57 SOUTH to I-24 EAST to NASHVILLE at EXIT 44.
3. Take I-24 EAST through Illinois and Kentucky and through Nashville to I-75 SOUTH to ATLANTA at EXIT 185A in Chattanooga.
4. Take I-75 SOUTH through Tennessee and Georgia to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435 in Florida. On this stretch, bypass Atlanta, Georgia by taking I-285 WEST BYPASS (EXIT 259 off I-75 and then EXIT 58 off I-285 to get back onto I-75 SOUTH) and bypass Macon, Georgia by taking I-475 SOUTH (EXIT 177 off I-75).
5. Follow signs to I-10 EAST to JACKSONVILLE. Take I-10 EAST to Jacksonville.