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Anemia

This category is for questions about the lack of red blood cells or hemoglobin called anemia: its symptoms, causes, and treatment.

936 Questions

What is One pleiotropic affect of sickle cell syndrome?

One pleiotropic effect of sickle cell syndrome is increased resistance to malaria. The genetic mutation that causes sickle cell disease also confers some protection against malaria infection, as the malaria parasite has difficulty surviving in the altered red blood cells of individuals with sickle cell trait.

People who are heterozygous for sickle cells disease are generally healthy because?

they have one normal hemoglobin gene that can produce functional hemoglobin to carry oxygen effectively, compensating for the abnormal hemoglobin produced by the gene for sickle cell disease. This keeps their red blood cells from sickling and causing blockages in blood vessels that lead to symptoms of the disease.

Megaloblastic anemia results from a deficiency of?

Megaloblastic anemia results from a deficiency of vitamin B12 or folic acid, both of which play a crucial role in DNA synthesis and red blood cell production. This deficiency leads to the production of abnormally large and immature red blood cells, causing anemia.

What are the dangerous mutations that occur in sickle cell anemia?

The dangerous mutation in sickle cell anemia is a point mutation in the HBB gene that results in the substitution of glutamic acid with valine in the beta-globin chain of hemoglobin. This leads to the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to take on a sickle shape, leading to various complications such as vaso-occlusive crises, anemia, and organ damage.

What body systems are most affected by sickle cell anemia?

Sickle cell anemia primarily affects the circulatory system and the immune system. The abnormal sickle-shaped red blood cells can block blood vessels, leading to complications such as pain episodes, organ damage, and an increased risk of infections.

What is a punnett square for sickle cell anemia?

In a Punnett square for sickle cell anemia, a capital "A" represents the normal hemoglobin gene and a lowercase "a" represents the sickle cell hemoglobin gene. When a parent with sickle cell trait (Aa) is crossed with another parent with sickle cell trait (Aa), there is a 25% chance of having a child with normal hemoglobin (AA), a 50% chance of having a child with sickle cell trait (Aa), and a 25% chance of having a child with sickle cell anemia (aa).

How does sickle cell disease effect your amune system?

Sickle cell disease can weaken the immune system by making individuals more susceptible to infections. This is because sickle-shaped red blood cells can become trapped in blood vessels, leading to reduced oxygen flow to organs like the spleen, which plays a key role in immune function. As a result, individuals with sickle cell disease may have difficulty fighting off infections effectively.

What is sickle-cell disease and how is this disorder inherited?

Sickle cell disease is a genetic disorder where red blood cells take on a "sickle" shape, causing blockages in blood vessels and leading to various complications. It is inherited in an autosomal recessive manner, meaning a child must inherit a sickle cell gene from both parents to develop the disease.

Why is it beneficial to have Sickle cell anemia if you live in Africa?

Sickle cell trait provides some protection against malaria, which is prevalent in Africa. This is because the plasmodium parasite causing malaria has difficulty surviving in red blood cells with abnormal hemoglobin, such as those in individuals with sickle cell trait. This offers a survival advantage in regions where malaria is common.

What type of anemia does a gene mutation cause?

A gene mutation can cause sickle cell anemia, a type of hemolytic anemia where red blood cells become crescent-shaped and rigid, leading to reduced oxygen delivery, pain, and organ damage.

Can you still be alive at age 14-15 with sickle cell anemia?

Yes, individuals with sickle cell anemia can live into adulthood with proper care and management of the condition. Regular medical check-ups, adherence to prescribed treatment plans, and healthy lifestyle choices can help improve quality of life and overall life expectancy for those with sickle cell anemia.

Why does sickle cell disease run in families yet is not present in every generation?

Sickle cell disease is an inherited genetic disorder caused by having two copies of the sickle cell gene. When both parents are carriers of the gene, each child has a 25% chance of inheriting the disease. Not every generation will have the disease because it depends on whether the gene is passed down from both parents.

What is sickle cell Trait The condition is Autosomal and there is Codominance between alleles what does this mean?

Sickle cell trait is a genetic condition where a person carries one abnormal hemoglobin gene and one normal gene. It is an autosomal condition because the gene is located on an autosome (non-sex chromosome) and shows codominance, meaning both alleles are expressed equally in the phenotype, resulting in a mix of normal and abnormal hemoglobin in the individual's red blood cells.

The polypeptide chain of hemoglobin that is designated beta and that when deficient or defective causes various anemias?

The polypeptide chain of hemoglobin designated beta is encoded by the HBB gene. Mutations in this gene can lead to conditions such as sickle cell anemia and beta thalassemia, causing a range of symptoms including anemia, fatigue, and complications related to reduced oxygen transport in the blood. Treatment options for these conditions include blood transfusions, medications, and in some cases, bone marrow transplant.

Does thalassemia related to blood group and Rh factor?

No, thalassemia is a genetic blood disorder that affects the production of hemoglobin in red blood cells. Blood group and Rh factor are determined by different genetic markers and are not directly linked to thalassemia.

In the genetic pedigree person U and her husband are considering having another child What is the percent chance that this child will develop sickle cell disease?

If both U and her husband are carriers of the sickle cell trait, there is a 25% chance that their child will develop sickle cell disease. This is because there is a 50% chance the child will inherit one sickle cell gene from each parent, resulting in the disease.

Sickling of RBCs can be induced in those with sickle-cell anemia?

Yes, sickle-cell anemia is a genetic disorder that affects hemoglobin, causing red blood cells to become rigid and sickle-shaped under certain conditions. This sickling process can lead to blockages in blood vessels, resulting in pain, damage to organs, and other complications.

Which types of mutation causes sickle cell anemia?

Sickle cell anemia is caused by a point mutation in the HBB gene, specifically a substitution of adenine for thymine in the sixth codon of the gene, resulting in the production of abnormal hemoglobin known as hemoglobin S.

What system is sickle cell a disease of?

Sickle cell disease is a genetic disorder that affects the red blood cells. It is caused by a mutation in the gene that affects the production of hemoglobin, a protein in red blood cells that helps carry oxygen throughout the body.

People who are heterozygous for sickle cell disease are generally healthy because of what?

People who are heterozygous for sickle cell disease possess one normal hemoglobin gene and one sickle hemoglobin gene, which allows them to produce enough normal red blood cells to prevent symptoms of the disease. This condition, known as sickle cell trait, provides some protection against malaria, as the presence of sickle hemoglobin can interfere with the parasite's life cycle within red blood cells.

How does sickle sell anemia affect a person mentally or intellectually?

Sickle cell anemia can lead to mental health challenges such as depression, anxiety, and cognitive impairment due to complications like chronic pain, organ damage, and reduced blood flow to the brain. These factors can impact a person's overall quality of life, ability to concentrate, memory, and decision-making skills. It is important for individuals with sickle cell anemia to receive comprehensive care that includes mental health support.

Did tiki barber have the sickle cell disease?

No, Tiki Barber does not have sickle cell disease. He is a retired NFL player who has been very active in various charitable causes, but sickle cell disease is not one of the health conditions he has publicly discussed.

How is sickle-cell disease a representation of codominance?

Sickle-cell disease is a representation of codominance because individuals who inherit one sickle-cell allele and one normal allele show a unique phenotype that is a mixture of both traits. In this case, individuals with the sickle-cell allele produce some normal and some sickle-shaped red blood cells, leading to the characteristic symptoms of the disease.

Do nicotine and sickle cell disease have any connections?

Research suggests that nicotine may worsen the symptoms of sickle cell disease by causing blood vessel constriction and increasing blood viscosity, which can trigger vaso-occlusive crises. Nicotine can also contribute to inflammation and oxidative stress, exacerbating the complications of sickle cell disease. It is advisable for individuals with sickle cell disease to avoid tobacco and nicotine products.