Phospholipids are a class of lipids and are a major component of all cell membranes as they can form lipid bilayer.

The further classification if a s follows:

Most phospholipids contain a diglyceride,a phosphate group,and a simple organic molecule such as choline.

1. Diacylglyceride structures

• • phosphatidic acid (phosphatidate) (PA)
  • phosphatidylethanolamine (cephalin) (PE)
  • phosphatidylecholine (lecithin) (PC)
  • phosphatidylserine(PS)
  • Phosphoinositides:
    • Phosphatidylinositol(PI)
    • Phosphatidylinositol phosphate(PIP)
    • Phosphatidylinositol bisphosphate(PIP2)
    • phosphatidylinositol triphosphate(PIP3)
• Phosphosphingolipids
  • Ceramide phosphorylcholine(sphingomylin)
  • Ceramide phosphorylethanolamene
  • Ceramide phosphorylglycerol

Phospholipids are a class of lipids and are a major component of all cell membranes as they can form lipid bilayer.

The further classification if a s follows:

Most phospholipids contain a diglyceride,a phosphate group,and a simple organic molecule such as choline.

1. Diacylglyceride structures

• • phosphatidic acid (phosphatidate) (PA)
  • phosphatidylethanolamine (cephalin) (PE)
  • phosphatidylecholine (lecithin) (PC)
  • phosphatidylserine(PS)
  • Phosphoinositides:
    • Phosphatidylinositol(PI)
    • Phosphatidylinositol phosphate(PIP)
    • Phosphatidylinositol bisphosphate(PIP2)
    • phosphatidylinositol triphosphate(PIP3)
• Phosphosphingolipids
  • Ceramide phosphorylcholine(sphingomylin)
  • Ceramide phosphorylethanolamene
  • Ceramide phosphorylglycerol

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Gaucher disease is an inherited disorder that affects many of the body's organs and tissues. The signs and symptoms of this condition vary widely among affected individuals. Researchers have described several types of Gaucher disease based on their characteristic features.

Type 1 Gaucher disease is the most common form of this condition. Type 1 is also called non-neuronopathic Gaucher disease because the brain and spinal cord (the central nervous system) are usually not affected. The features of this condition range from mild to severe and may appear anytime from childhood to adulthood. Major signs and symptoms include enlargement of the liver and spleen (hepatosplenomegaly), a low number of red blood cells (anemia), easy bruising caused by a decrease in blood platelets (thrombocytopenia), lung disease, and bone abnormalities such as bone pain, fractures, and Arthritis.

Types 2 and 3 Gaucher disease are known as neuronopathic forms of the disorder because they are characterized by problems that affect the central nervous system. In addition to the signs and symptoms described above, these conditions can cause abnormal eye movements, seizures, and brain damage. Type 2 Gaucher disease usually causes life-threatening medical problems beginning in infancy. Type 3 Gaucher disease also affects the nervous system, but tends to progress more slowly than type 2.

The most severe type of Gaucher disease is called the perinatal lethal form. This condition causes severe or life-threatening complications starting before birth or in infancy. Features of the perinatal lethal form can include extensive swelling caused by fluid accumulation before birth (hydrops fetalis); dry, scaly skin (ichthyosis) or other skin abnormalities; hepatosplenomegaly; distinctive facial features; and serious neurological problems. As its name indicates, most infants with the perinatal lethal form of Gaucher disease survive for only a few days after birth.

Another form of Gaucher disease is known as the cardiovascular type because it primarily affects the heart, causing the heart valves to harden (calcify). People with the cardiovascular form of Gaucher disease may also have eye abnormalities, bone disease, and mild enlargement of the spleen (splenomegaly).

Gaucher disease occurs in 1 in 50,000 to 100,000 people in the general population. Type 1 is the most common form of the disorder, and occurs more frequently in people of Ashkenazi (eastern and central European) Jewish heritage than in those with other backgrounds. This condition affects 1 in 500 to 1,000 people of Ashkenazi Jewish heritage. The other forms of Gaucher disease are uncommon, and do not occur more frequently in people of Ashkenazi Jewish descent.

Mutations in the GBA gene cause Gaucher disease.

The GBA gene provides instructions for making an enzyme called beta-glucocerebrosidase. This enzyme breaks down a fatty substance called glucocerebroside into a sugar (glucose) and a simpler fat molecule (ceramide). Mutations in the GBA gene greatly reduce or eliminate the activity of beta-glucocerebrosidase. Without enough of this enzyme, glucocerebroside and related substances can build up to toxic levels within cells. Tissues and organs are damaged by the abnormal accumulation and storage of these substances, causing the characteristic features of Gaucher disease.

Read more about the GBA gene.

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Gaucher disease is an inherited disorder that affects many of the body's organs and tissues. The signs and symptoms of this condition vary widely among affected individuals. Researchers have described several types of Gaucher disease based on their characteristic features.

Type 1 Gaucher disease is the most common form of this condition. Type 1 is also called non-neuronopathic Gaucher disease because the brain and spinal cord (the central nervous system) are usually not affected. The features of this condition range from mild to severe and may appear anytime from childhood to adulthood. Major signs and symptoms include enlargement of the liver and spleen (hepatosplenomegaly), a low number of red blood cells (anemia), easy bruising caused by a decrease in blood platelets (thrombocytopenia), lung disease, and bone abnormalities such as bone pain, fractures, and arthritis.

Types 2 and 3 Gaucher disease are known as neuronopathic forms of the disorder because they are characterized by problems that affect the central nervous system. In addition to the signs and symptoms described above, these conditions can cause abnormal eye movements, seizures, and brain damage. Type 2 Gaucher disease usually causes life-threatening medical problems beginning in infancy. Type 3 Gaucher disease also affects the nervous system, but tends to progress more slowly than type 2.

The most severe type of Gaucher disease is called the perinatal lethal form. This condition causes severe or life-threatening complications starting before birth or in infancy. Features of the perinatal lethal form can include extensive swelling caused by fluid accumulation before birth (hydrops fetalis); dry, scaly skin (ichthyosis) or other skin abnormalities; hepatosplenomegaly; distinctive facial features; and serious neurological problems. As its name indicates, most infants with the perinatal lethal form of Gaucher disease survive for only a few days after birth.

Another form of Gaucher disease is known as the cardiovascular type because it primarily affects the heart, causing the heart valves to harden (calcify). People with the cardiovascular form of Gaucher disease may also have eye abnormalities, bone disease, and mild enlargement of the spleen (splenomegaly).

Gaucher disease occurs in 1 in 50,000 to 100,000 people in the general population. Type 1 is the most common form of the disorder, and occurs more frequently in people of Ashkenazi (eastern and central European) Jewish heritage than in those with other backgrounds. This condition affects 1 in 500 to 1,000 people of Ashkenazi Jewish heritage. The other forms of Gaucher disease are uncommon, and do not occur more frequently in people of Ashkenazi Jewish descent.

Mutations in the GBA gene cause Gaucher disease.

The GBA gene provides instructions for making an enzyme called beta-glucocerebrosidase. This enzyme breaks down a fatty substance called glucocerebroside into a sugar (glucose) and a simpler fat molecule (ceramide). Mutations in the GBA gene greatly reduce or eliminate the activity of beta-glucocerebrosidase. Without enough of this enzyme, glucocerebroside and related substances can build up to toxic levels within cells. Tissues and organs are damaged by the abnormal accumulation and storage of these substances, causing the characteristic features of Gaucher disease.

Read more about the GBA gene.

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Examples of biologically important fatty acids are the eicosanoids, derived primarily from arachidonic acid and eicosapentaenoic acid, which include prostaglandins, leukotrienes, and thromboxanes. Other major lipid classes in the fatty acid category are the fatty esters and fatty amides. Fatty esters include important biochemical intermediates such as wax esters, fatty acid thioester coenzyme A derivatives, fatty acid thioester ACP derivatives and fatty acid carnitines. The fatty amides include N-acyl ethanolamines, such as the cannabinoid neurotransmitter anandamide.

Additional subclasses of glycerolipids are represented by glycosylglycerols, which are characterized by the presence of one or more sugar residues attached to glycerol via a glycosidic linkage. Examples of structures in this category are the digalactosyldiacylglycerols found in plant membranes and seminolipid from mammaliansperm cells.

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parasols, paravane, parawing, parazoan, parbaked, parbakes, parboils, parceled, parcener, parchesi, parching, parchisi, parclose, pardners, pardoned, pardoner, parecism, pareiras, parental, parented, parergon, paretics, parfaits, parflesh, parfocal, pargeted, pargings, parhelia, parhelic, parietal, parietes, parishes, parities, parkades, parkette, parkings, parkland, parklike, parkways, parlance, parlando, parlante, parlayed, parleyed, parleyer, parlours, parmesan, parodied, parodies, parodist, parolees, paroling, paronyms, paroquet, parosmia, parotids, parotoid, paroxysm, parquets, parridge, parriers, parritch, parroket, parroted, parroter, parrying, parsable, parsleys, parsnips, parsonic, partaken, partaker, partakes, parterre, partials, partible, particle, partiers, partings, partisan, partitas, partizan, partlets, partners, partyers, partying, parvenue, parvenus, parvises, parvolin, peracids, percales, perceive, percents, percepts, perchers, perching, percoids, perdured, perdures, peregrin, pereions, pereopod, perfecta, perfecto, perfects, perforce, performs, perfumed, perfumer, perfumes, perfused, perfuses, pergolas, perianth, periapts, periblem, pericarp, pericope, periderm, peridial, peridium, peridots, perigeal, perigean, perigees, perigons, perigyny, periling, perillas, perilled, perilous, perilune, perineal, perineum, periodic, periodid, periotic, peripety, peripter, periques, perisarc, perished, perishes, periwigs, perjured, perjurer, perjures, perkiest, perlites, perlitic, permeant, permease, permeate, permuted, permutes, peroneal, perorate, peroxide, peroxids, perpends, perpents, persalts, persists, personae, personal, personas, perspire, perspiry, persuade, pertains, pertness, perturbs, perusals, perusers, perusing, pervaded, pervader, pervades, perverse, perverts, pervious, phrasing, phratral, phratric, phreaked, phreaker, phreatic, piracies, piraguas, piranhas, pirarucu, pirating, piriform, pirogies, pirogues, piroques, piroshki, pirozhki, pirozhok, porcinis, porkiest, porkpies, porkwood, porosity, porously, porphyry, porpoise, porridge, portable, portably, portaged, portages, portaled, portance, portapak, portends, portents, porthole, porticos, portiere, portions, portless, portlier, portrait, portrays, portress, portside, purblind, purchase, purebred, pureeing, pureness, purflers, purfling, purgings, purified, purifier, purifies, puristic, puritans, purities, purlieus, purlines, purlings, purloins, purplest, purpling, purplish, purports, purposed, purposes, purpuras, purpures, purpuric, purpurin, pursiest, purslane, pursuant, pursuers, pursuing, pursuits, purtiest, purulent, purveyed, purveyor, purviews, pyralids, pyramids, pyranoid, pyranose, pyrenoid, pyrexial, pyrexias, pyridine, pyriform, pyritous, pyrogens, pyrology, pyrolyze, pyronine, pyrostat, pyroxene, pyrrhics, pyrroles, pyrrolic, pyruvate, qurushes, rarebits, rarefied, rarefier, rarefies, rareness, rareripe, rarified, rarifies, rarities, reracked, reraised, reraises, rerecord, reremice, reremind, rerented, rerepeat, rereview, rereward, rerising, rerolled, reroller, reroofed, rerouted, reroutes, rorquals, ruralise, ruralism, ruralist, ruralite, rurality, ruralize, saraband, sarcasms, sarcenet, sarcinae, sarcinas, sarcoids, sarcomas, sardanas, sardined, sardines, sardonic, sardonyx, sargasso, sarkiest, sarmenta, sarments, sarodist, sarsenet, sarsnets, sartorii, scrabble, scrabbly, scragged, scraggly, scraichs, scraighs, scramble, scramjet, scrammed, scrannel, scrapers, scrapies, scraping, scrapped, scrapper, scrapple, scratchy, scrawled, scrawler, screaked, screamed, screamer, screechy, screeded, screened, screener, screwers, screwier, screwing, screwups, scribble, scribbly, scribers, scribing, scrieved, scrieves, scrimped, scrimper, scrimpit, scripted, scripter, scriving, scrofula, scrolled, scrooges, scrooped, scrootch, scrotums, scrouged, scrouges, scrounge, scroungy, scrubbed, scrubber, scrummed, scrunchy, scrupled, scruples, scrutiny, seraglio, seraphic, seraphim, seraphin, serenade, serenata, serenate, serenely, serenest, serenity, serfages, serfdoms, serfhood, serflike, sergeant, sergings, serially, seriated, seriates, seriatim, sericins, seriemas, seriffed, seringas, serjeant, sermonic, serology, serosity, serotine, serotiny, serotype, serovars, serpents, serpigos, serranid, serrated, serrates, serrying, servable, servants, serviced, servicer, services, servings, servitor, shrapnel, shredded, shredder, shrewder, shrewdie, shrewdly, shrewing, shrewish, shrieked, shrieker, shrieval, shrieved, shrieves, shrilled, shriller, shrimped, shrimper, shrining, shrinker, shrivels, shrivers, shriving, shroffed, shrouded, shrugged, shrunken, sirenian, sirloins, siroccos, sirupier, siruping, sirvente, skreeghs, skreighs, sorbable, sorbates, sorbents, sorbitol, sorboses, sorcerer, sordidly, sordines, sorehead, soreness, sorghums, soricine, soroches, sororate, sorority, sorption, sorptive, sorriest, sorrowed, sorrower, sortable, sortably, spraddle, sprained, sprattle, sprawled, sprawler, sprayers, spraying, spreader, sprigged, sprigger, sprights, springal, springed, springer, springes, sprinkle, sprinted, sprinter, spritzed, spritzer, spritzes, sprocket, sprouted, sprucely, sprucest, sprucier, sprucing, spryness, straddle, strafers, strafing, straggle, straggly, straight, strained, strainer, straiten, straiter, straitly, stramash, stramony, stranded, strander, stranger, stranges, strangle, strapped, strapper, strasses, strategy, stratify, stratous, stratums, stravage, stravaig, strawhat, strawier, strawing, strayers, straying, streaked, streaker, streamed, streamer, streeked, streeker, strength, stressed, stresses, stressor, stretchy, strettas, strettos, streusel, strewers, strewing, striated, striates, striatum, stricken, strickle, stricter, strictly, stridden, strident, striders, striding, stridors, strigils, strigose, strikers, striking, stringed, stringer, stripers, stripier, striping, stripped, stripper, strivers, 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tarragon, tarriers, tarriest, tarrying, tarsiers, tartanas, tartaric, tartiest, tartlets, tartness, tartrate, tartufes, tartuffe, tarweeds, terabyte, teraflop, teraohms, teraphim, teratism, teratoid, teratoma, terbiums, tercelet, terebene, tergites, teriyaki, terminal, terminus, termites, termitic, termless, termtime, ternions, terpenes, terpenic, terpinol, terraced, terraces, terrains, terranes, terrapin, terraria, terrases, terrazzo, terreens, terrella, terrenes, terrible, terribly, terriers, terrific, terrines, tertials, tertians, tertiary, terylene, thraldom, thralled, thrashed, thrasher, thrashes, thrawart, thrawing, thrawnly, threaded, threader, threaped, threaper, threated, threaten, threeped, threnode, threnody, threshed, thresher, threshes, thrilled, thriller, thrivers, thriving, throated, throbbed, throbber, thrombin, thrombus, thronged, throning, throstle, throttle, throwers, throwing, thrummed, thrummer, thruputs, thrushes, thrusted, thruster, thrustor, thruways, tiredest, 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unrooted, unrounds, unrulier, unrushed, unrusted, upraised, upraiser, upraises, upreared, uprights, uprisers, uprising, uprivers, uprootal, uprooted, uprooter, uproused, uprouses, uprushed, uprushes, utricles, utriculi, varactor, variable, variably, variance, variants, variated, variates, varicose, variedly, varietal, variform, variolar, variolas, varioles, variorum, varistor, varletry, varments, varmints, varnishy, varoomed, veracity, verandah, verandas, veratria, veratrin, veratrum, verbally, verbatim, verbenas, verbiage, verbiles, verbless, verboten, verdancy, verderer, verderor, verdicts, verditer, verdured, verdures, verecund, vergence, verified, verifier, verifies, verismos, veristic, verities, verjuice, vermeils, vermoulu, vermouth, vermuths, vernacle, vernally, vernicle, verniers, vernixes, veronica, verrucae, verrucas, versants, verseman, versemen, versicle, versines, versions, vertebra, vertexes, vertical, vertices, verticil, vertigos, vervains, viragoes, virelais, virelays, viremias, virgates, virginal, virgules, viricide, viridian, viridity, virilely, virilism, virility, virilize, virology, virtuosa, virtuose, virtuosi, virtuoso, virtuous, virucide, virulent, virusoid, voracity, vorlages, vortexes, vortical, vortices, warblers, warbling, warcraft, wardenry, wardless, wardress, wardrobe, wardroom, wardship, wareroom, warfares, warfarin, warheads, warhorse, wariness, warisons, warlocks, warlords, warmaker, warmness, warmouth, warnings, warpages, warpaths, warplane, warpower, warpwise, warragal, warrants, warranty, warrener, warrigal, warriors, warships, warslers, warsling, warstled, warstler, warstles, warthogs, wartiest, wartimes, wartless, wartlike, warworks, weregild, werewolf, wergelds, wergelts, wergilds, wiredraw, wiredrew, wirehair, wireless, wirelike, wiretaps, wireways, wirework, wireworm, wiriness, wordages, wordbook, wordiest, wordings, wordless, wordplay, workable, workably, workaday, workbags, workboat, workbook, workdays, workfare, workflow, workfolk, workhour, workings, workless, workload, workmate, workouts, workroom, workshop, workweek, wormgear, wormhole, wormiest, wormlike, wormroot, wormseed, wormwood, wornness, worriers, worrited, worrying, worsened, worships, worsteds, worsting, worthful, worthier, worthies, worthily, worthing, wurtzite, xerosere, yardages, yardarms, yardbird, yardland, yardwand, yardwork, yarmelke, yarmulke, zaratite, zareebas, zarzuela, zircaloy, zirconia, zirconic, zorillas, zorilles, zorillos

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