The red blood cells stack up like coins. http://en.wikipedia.org/wiki/Rouleaux
Rouleaux refers to the stacking of red blood cells (erythrocytes) in human blood. Rouleaux formation is enhanced in the presence of increased plasma proteins, leading to an increased erythrocyte sedimentation rate (ESR).
Multiple Myeloma
Rouleaux formation is the stacking of red blood cells like a roll of coins, often seen in conditions like multiple myeloma. True agglutination is the clumping of red blood cells due to antibody-antigen interaction, such as in blood typing reactions. The key difference is that rouleaux formation involves cells stacking on top of each other, whereas true agglutination involves cells clumping together.
Rouleaux formation occurs when red blood cells form rolls or stacks. If not due to an artifact, such as a result of not preparing the blood smear soon enough after placing the blood on the slide, it may be due to the presence of high concentrations of abnormal globulins or fibrinogen. This formation is found in multiple myeloma and macroglobulinemia.
Rouleaux formation, which is the stacking of red blood cells, does not typically occur in vivo due to the flow dynamics in blood vessels. The force of blood flow helps to separate and prevent red blood cells from sticking together. Additionally, the presence of plasma proteins like albumin helps to maintain the cells in a dispersed state.
clinical importance of pleural recess
Rouleaux formation occurs when red blood cells stick together in a stack, resembling a coin roll. This can be caused by increased levels of plasma proteins in the blood, such as fibrinogen or immunoglobulins, leading to decreased repulsion forces between cells. It is commonly seen in conditions like inflammation, infections, and certain cancers.
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look for a paper being published in "The Oncologist" later this year (2008)
Rouleaux formation occurs when red blood cells adhere to each other in stacks due to increased levels of plasma proteins like fibrinogen or immunoglobulins. This process can be seen in conditions like inflammation, infection, or certain blood disorders, and it helps red blood cells adhere and flow smoothly through narrow blood vessels.
The condition of red blood cells stacked like coins is known as Rouleaux formation. This is a reversible phenomenon often seen in conditions with high levels of acute-phase proteins, such as inflammation or infection, where the proteins cause the red blood cells to stick together.