A topical medication is a skin medication, and the "base" is the "stuff" (cream, ointment, gel, lotion, spray) into which the therapeutic medication is mixed.
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A topical preparation base is the foundation of a topical medication that carries the active ingredients. It provides a vehicle for the active ingredients to be applied to the skin for localized effects. Common bases include creams, ointments, gels, and lotions, which can affect the absorption, texture, and application of the medication.