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No, replication does not require oxygen. Replication is the process of copying DNA or RNA, which can occur in the absence of oxygen. Oxygen is not directly involved in the process of DNA replication itself.
The energy releasing process that does not require oxygen is called anaerobic respiration. This is mainly used by organisms who live in areas with little oxygen such as at the bottom of the ocean.
Anaerobic respiration is the energy-releasing process that does not require oxygen. It involves the breakdown of glucose to produce ATP in the absence of oxygen.
Replication typically occurs in the nucleus of a eukaryotic cell and the cytoplasm of a prokaryotic cell. In eukaryotic cells, DNA replication takes place in the nucleus, while in prokaryotic cells like bacteria, replication occurs in the cytoplasm.
A common misconception is that air is mostly oxygen. 78% of air is nitrogen and only 20% is oxygen. Nitrogen is inert and flows in and out of our lungs untouched, but we require oxygen to live, so it gets absorbed.
When you lack oxygen, your muscles can still produce energy through a process called anaerobic metabolism. This metabolic pathway does not require oxygen and produces energy quickly but less efficiently than aerobic metabolism. As a result, lactic acid may build up in the muscles, causing fatigue and soreness.