Prothrombin time (PT)

Answer 1

test of synthetic capacity of liver with albumin....time to make a fibrin clot....elevated PT (taking too long)....most commonly used to follow coumadin

Answer 2

Definition

Prothrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot.

See also: Partial thromboplastin time (PTT)

Alternative Names

PT; Pro-time

How the test is performed

The health care provider uses a needle to take blood from one of your veins. The blood collects into an airtight container. You may be given a bandage to stop any bleeding. If you are taking a medicine called heparin, you will be watched for signs of bleeding.

The laboratory specialist will add chemicals to the blood sample and see how long it takes for the plasma to clot.

How to prepare for the test

Your doctor may tell you to stop taking certain drugs before the test. For example, blood thinners can affect the results of this test.

Do not stop taking any medicine without first talking to your doctor.

How the test will feel

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed

Your doctor may order this test if you have signs of a blood clotting disorder.

When you bleed, the body launches a series of activities that help the blood clot. This is called the coagulation cascade. The PT test looks at special proteins (called coagulation factors) that are involved in this event, and measures their ability to help blood clot.

It measures:

• Factor I (fibrinogen)
• Factor II (prothrombin)
• Factor V
• Factor VII
• Factor X

Normal Values

The normal range is 11 to 13.5 seconds. The PT result will be longer in persons who take blood thinners.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What abnormal results mean

When any of the blood clotting factors are lacking or not working properly, the PT is prolonged.

Increased PT may be due to:

• Bile duct obstruction
• Cirrhosis
• Disseminated intravascular coagulation
• Hepatitis
• Liver disease
• Malabsorption
• Vitamin Kdeficiency
• Coumadin (warfarin) therapy
• Factor VII deficiency
• Factor X deficiency
• Factor II (prothrombin) deficiency
• Factor V deficiency
• Factor I (fibrinogen) deficiency

What the risks are

This test is often done on people who may have bleeding problems. The risks of bleeding and hematoma in these patients are slightly greater than for people without bleeding problems. In general, risks of any blood test may include:

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)
• Multiple punctures to locate veins

References

Schafer AI. Approach to the patient with bleeding and thrombosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 178.

Answer 3

Definition

Prothrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot.

See also: Partial thromboplastin time (PTT)

Alternative Names

PT; Pro-time; Anticoagulant-prothrombin time

How the test is performed

The health care provider uses a needle to take blood from one of your veins. The blood collects into an airtight container. You may be given a bandage to stop any bleeding. If you are taking a medicine called heparin, you will be watched for signs of bleeding.

The laboratory specialist will add chemicals to the blood sample and see how long it takes for the plasma to clot.

How to prepare for the test

Make sure your doctor knows about all the medicines you are taking, including over-the-counter medicines, herbs, and supplements. Your doctor may tell you to stop taking certain drugs before the test. For example, blood thinners can affect the results of this test.

Do not stop taking any medicine without first talking to your doctor.

How the test will feel

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed

Your doctor may order this test if you have signs of a blood clotting disorder.

If you are taking a blood thinning medicine called warfarin, your health care provider will check your PT or prothrombin time regularly.

When you bleed, the body launches a series of activities that help the blood clot. This is called the coagulation cascade. The PT test looks at special proteins (called coagulation factors) that are involved in this event, and measures their ability to help blood clot.

Normal Values

The normal range for someone who is not taking a blood thinner medication is 11 - 13.5 seconds.

The PT result will be longer in persons who take blood thinners. Ask your doctor what result is right for you.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

What abnormal results mean

When any of the blood clotting factors are lacking or not working properly, the PT is prolonged.

A PT result that is too high or too low in someone who is taking warfarin (Coumadin) may be due to:

• The wrong dose of medication
• Drinking alcohol
• Taking certain over-the-counter medicines, vitamins, supplements, cold medicines, antibiotics, or other drugs
• Eating a food that changes the way the blood thinning medication works in your body

Increased PT may also be due to:

• Bile duct obstruction
• Disseminated intravascular coagulation
• Liver disease
• Malabsorption
• Vitamin Kdeficiency
• Factor VII deficiency
• Factor X deficiency
• Factor II (prothrombin) deficiency
• Factor V deficiency
• Factor I (fibrinogen) deficiency

What the risks are

This test is often done on people who may have bleeding problems. The risks of bleeding and hematoma in these patients are slightly greater than for people without bleeding problems. In general, risks of any blood test may include:

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)
• Multiple punctures to locate veins

References

Schafer AI. Approach to the patient with bleeding and thrombosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 178.

Schmaier AH. Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 122.

Reviewed By

Review Date: 02/13/2011

David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.