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Neostigmine is a potent cholenergic which if given alone can cause a sever cholinergic crisis. the symptoms are usually described as SLUD BB M

Salivation

Lacrimation

Urination

Deification

Bradycardia

Bronchoconstriction

Miosis

If given with a anticholinergic like glycopyrolate, those actions are blocked and the only real action left is neostigmines' ability to block acetylcholinesterase which will allow acetylcholine to build up and allow muscles to work or

function better (stronger)

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Q: Why is neostigmine used with anticholinergic?
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What does anticholinergic mean?

Anticholinergic refers to drugs or substances that block the action of the neurotransmitter acetylcholine in the nervous system. They are commonly used to treat conditions like overactive bladder, Parkinson's disease, and motion sickness. However, anticholinergic medications can also have side effects such as dry mouth, blurred vision, and confusion.


How is neostigmine chemically used to treat myasthenia gravis?

Neostigmine is a competitive irreversible inhibitor of Acetylcholinesterase (AChE), an enzyme responsible for breaking down acetylcholine (ACh). Myasthenia gravis is caused by the body producing too little ACh receptors. As stimulating the ACh receptors is needed for nervous transmission, the nerve signals cannot be transmitted causing muscle weakness and fatigue. Neostigmine is hence used to inhibit AChE so that less ACh gets broken down. This leads to more ACh binding to the ACh receptors causing muscular contraction.


Anti cholinergic drugs?

Anticholinergic drugs are substances used to help reduce and block the effects of acetylcholine. They are mainly used for the treatment of stomach cramps, motion sickness and ulcers. Some anticholinergic drugs include: Ipatropium Bromide Oxitropium Bromide Tiotropium Glycopyrrolate