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I think you have your terms confused, the term glucogenolysis is, I believe, a mix-up of the term glycogenolysis, which is the breakdown of stored glycogen into glucose. Gluconeogenesis is the formation of new glucose from amino acids from protein breakdown and glycerin from fat breakdown.
Glucogenolysis does not occur as glucose is not required to split. Instead, when the blood glucose level is too high, Glycogenesis occurs in which glucose is converted to the storage form glycogen.
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Name two principal sources of blood glucose?
During fasting the glucose is relaesed from intracellular glycogen stores in the liver (produced by glucogenolysis). After a meal blood glucose is acquired from the diet.
What causes a build up of ketones in the blood?
When Insulin level is decreased the pathways such as glycolysis, Glucogenolysis, fatty acid synthesis decreases as a result glucagon stimulates gluconeogenesis, fatty acid lysis, acetyl coA is diverted to form ketone bodies , ketogenic amino acids stored as proteins will form ketones by this ketone bodies increases in blood .. this happens even in high starvation, in DM also.
How does ketones accumulate in the blood?
When Insulin level is decreased the pathways such as glycolysis, Glucogenolysis, fatty acid synthesis decreases as a result glucagon stimulates gluconeogenesis, fatty acid lysis, acetyl coA is diverted to form ketone bodies , ketogenic amino acids stored as proteins will form ketones by this ketone bodies increases in blood .. this happens even in high starvation, in DM also.
What are the causes of hyperglycemia?
Mechanism of fasting hyperglycemia: Raised blood sugar post prandial, delayed increased production of insulin due to most probably defect/abnormality of B cell pancreas, in turn, endogenic glucose production (gluconeogenesis, glucogenolysis) freely caused raised in fasting blood sugar. By: Dr B Sutopo SpPD, K-GEH, FINASIM
