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If you are talking about pathognomonic (sounds like your spelling), it means that a certain pathophysiology is unique to a certain disease. So, if a patient displays the certain pathognomonic symptoms, it can be concluded with confidence that they have the disease that matches. Most symptoms are not pathognomonic, so additional testing, information, etc is required to rule out diseases in order to make a diagnosis.
I'm not sure if you use it for only the symptoms or the disease as well, though.
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