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During the copying of the DNA there is room for error much like a game of phone-call where you pass a phrase down a group of people and it was change depending on how people hear it. (not the best answer but it works)

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โˆ™ 14y ago
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โˆ™ 8mo ago

The high mutation rate of mitochondrial DNA is thought to be due to the lack of protective histones and repair mechanisms, as well as the close proximity to reactive oxygen species produced during respiration. This leads to an accumulation of mutations over time.

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Q: Why is mitochondrial DNA mutation rate so high?
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Related questions

Why mitochondria mutation study will isolated Genomic DNA instead of Mitochondrial DNA?

Yes,I don't know!Tell me..!


Why does the mitochondrial disease exist?

It exists because the DNA in mitochondria is duplicated without the checkpoints that nuclear DNA duplication has. Mitochondrial DNA disorders may occur spontaneously and relatively often.


Do mutations happen a lot?

Statistically speaking, the fidelity of DNA polymerases is very high and they usually make 1 mistake for every 1000000000 base pairs that they add to a growing DNA strand. However, there are many external methods of inducing mutations, most notably by chemicals and radiation. Therefore it is estimated that the genomic DNA mutation rate per generation for humans is one in 40000000 base pairs. However, human mitochondrial DNA curiously carries a much higher mutation rate per generation of about 1 in 37000 to 1 in 333000 base pairs. For the mutation rates of other organisms, follow the link below.


When was Mitochondrial DNA - journal - created?

Mitochondrial DNA - journal - was created in 1980.


Is mitochondrial DNA linear or circular in structure?

Mitochondrial DNA is circular in structure.


Who shares your mitochondrial DNA?

Mitochondrial DNA comes from the mother, so the mother's maternal line and all her children share the same mitochondrial DNA.


Does mitochondrial DNA contain introns?

Yes, mitochondrial DNA does not contain introns. Mitochondrial DNA is a circular molecule that lacks introns, which are non-coding regions found in nuclear DNA.


Where do you get your mitochondrial DNA from?

In most organisms, including humans, the mitochondrial DNA is inherited from the mother.


What does mitochondrial DNA code for?

Mitochondrial DNA codes for certain proteins that are essential for the function of the mitochondria, the cell's powerhouse. It also contains genes involved in energy production through oxidative phosphorylation. Mitochondrial DNA is separate from the nuclear DNA and is passed down maternally.


Which is larger Human mitochondrial DNA or yeast mitochondrial DNA?

Yeast's is (~78kb), while human's is about 17kb


How does the inheritance of mitochondrial DNA different found in the nucleus of cells?

Mitochondrial DNA is only inherited from the mother, while nuclear DNA is inherited from both parents. Mitochondrial DNA is circular and does not undergo recombination, whereas nuclear DNA is linear and can recombine during meiosis. Mitochondrial DNA codes for a small number of genes related to energy production, while nuclear DNA contains genes that determine various traits and characteristics.


How does mitochondrial DNA differ from nuclear DNA in terms of structure and function?

Mitochondrial DNA is smaller and circular in structure, while nuclear DNA is larger and linear. Mitochondrial DNA is only inherited from the mother, while nuclear DNA is inherited from both parents. Mitochondrial DNA is responsible for producing energy in the form of ATP, while nuclear DNA contains the majority of an organism's genetic information.