Oxygen.
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The highest oxygen affinity is demonstrated by fetal hemoglobin (HbF), due to its higher affinity for oxygen compared to adult hemoglobin (HbA). This allows for efficient oxygen transfer from the mother to the fetus in the placenta.
It's the final electron acceptor, due to its high affinity for electrons.
Oxygen has 8 electrons. The electron configuration for oxygen is 1s^2 2s^2 2p^4. Therefore, its highest energy electrons are in the 2p orbital.
The removal of one electron from an oxygen atom requires more energy than adding two electrons because oxygen is in Group 16 of the periodic table, which means it has a higher affinity for gaining electrons (higher electron affinity) than losing them.
First EA is usually exothermic as energy is released when the nucleus attarcts an electron is larger than the energy taken in to overcome their inter-electronic repulsion. Second EA is always endothermic since electron is added to a negative ion. Energy is needed to overcome the repulsion between the two negatively charged species.