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If a subsance is applied to a cell that makes the membrane more permeable to ions, the interior voltage changes. If the interior voltage becomes more positive (say from Ð70 mV to Ð60 mV), this is called a depolarization. If the interior voltage becomes more negative (say from Ð70 mV to Ð80 mV) it's called a hyperpolarization.

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Q: What would happen to the membrane potential if a substance that makes the membrane permeable to ions is added to the cell?
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The nucleus would be damaged.


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The cell would die as it couldn't maintain homeostasis.


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