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Tropical spastic paraparesis (TSP) is a slowly progressive spastic paraparesis caused by the human T-cell lymphotropic virus-1 (HTLV-1), with an insidious onset in adulthood.
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∙ 13y ago
Tropical spastic paraparesis, also known as HTLV-1-associated myelopathy (HAM), is a rare neurological condition caused by the human T-cell lymphotropic virus type 1 (HTLV-1). It is characterized by weakness and stiffness in the legs, leading to difficulty walking. There is currently no cure for this condition, and treatment focuses on managing symptoms.
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How is tropical spastic paraparesis cured?
Tropical spastic paraparesis (TSP) does not have a cure. Treatment focuses on managing symptoms and slowing down the progression of the disease. This may include physical therapy, medications to manage symptoms like spasticity and pain, and lifestyle modifications to improve quality of life.
How long can tropical spastic paraparesis remain dormant?
Tropical spastic paraparesis (TSP), caused by the HTLV-1 virus, can remain dormant for many years, even decades, before symptoms appear. However, not everyone infected with HTLV-1 will develop TSP. Factors such as genetic predisposition and immune response can influence whether the virus becomes active and causes symptoms.
Is human t-lymphotropic virus type 1 a blood borne pathogen?
Yes, human T-lymphotropic virus type 1 (HTLV-1) can be transmitted through blood transfusions, sharing needles, and from mother to child during childbirth or breastfeeding. It primarily infects T cells and can lead to diseases such as adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis.
What is hereditary spastic paraplegia?
Hereditary spastic paraplegia (HSP) is a group of inherited neurological disorders that primarily affect the legs, causing progressive stiffness and weakness. It is characterized by spasticity and difficulty walking, and the severity can vary widely among individuals. HSP is caused by genetic mutations that disrupt the normal functioning of nerve cells in the spinal cord.
Is a tropical storm the same as tropical depression?
No. A tropical depression is a tropical cyclone with winds under 39 mph. A tropical storm is a tropical cyclone with winds from 39 mph to 73 mph.
How long can tropical spastic paraparesis remain dormant?
Tropical spastic paraparesis (TSP), caused by the HTLV-1 virus, can remain dormant for many years, even decades, before symptoms appear. However, not everyone infected with HTLV-1 will develop TSP. Factors such as genetic predisposition and immune response can influence whether the virus becomes active and causes symptoms.
Where is tropical spastic paraparesis found in the U.S.?
isolated cases have been diagnosed in the southeastern United States and other places in the United States
How is tropical spastic paraparesis cured?
Tropical spastic paraparesis (TSP) does not have a cure. Treatment focuses on managing symptoms and slowing down the progression of the disease. This may include physical therapy, medications to manage symptoms like spasticity and pain, and lifestyle modifications to improve quality of life.
Where does tropical spastic paraparesis occur?
TSP is most frequently found in: the Caribbean, Japan, the Seychelles Islands, regions of South America, western Africa
How is tropical spastic paraparesis diagnosed?
Infectious disease specialists use blood tests and magnetic resonance imaging (MRI) of the spinal cord to diagnose this condition.
Who is most likely to contract tropical spastic paraparesis?
TSP usually affects adults between the ages of 30 and 40, and is far more common in women than in men.
What is the purpose of physical therapy for tropical spastic paraparesis?
Physical therapy is designed to help restore and maintain useful movements or functions and prevent complications such as frozen joints, contractures, or bedsores.
What are some less common side effects of tropical spastic paraparesis?
20% of patients with TSP may also experience: deafness, double vision, dysmetria, exaggerated reflexes, facial paralysis, tremor.
What is the cause of tropical spastic paraparesis?
The cause of HAM/TSP is still a matter of debate. Three hypotheses are considered by scientists as the most likely cause of TSP: direct toxicity, autoimmunity, and bystander damage.
What medications are used to treat tropical spastic paraparesis?
significant improvement has been reported in the condition of TSP patients treated with corticosteroids. These drugs are believed to alleviate symptoms by suppressing the immune system's response to the virus that causes them.
What are the primary symptoms of tropical spastic paraparesis?
the body's immune response may injure nerve tissue, causing symptoms that include bladder abnormalities, leg pain, loss of feeling in the feet, tingling sensations, and unpleasant sensations when the skin is touched.
Where is tropical spastic paraparesis found?
TSP is caused by the HTLV-1 virus, which also causes leukemia. The virus can be spread through the placenta, and also through blood transfusions, breast-feeding, contaminated needles, and sexual contact.
