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HA ==> H+ + A-Ka = [H+][A-][HA] and from pH = 2.31, calculated [H+] = 4.89x10^-3 M
Ka = (4.89x10^-3)(4.89x10^-3)/0.012
Ka = 1.99x10^-3
pKa = 2.70
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What is pka value for paliperidone?
The pKa value for paliperidone is about 4.5. This means that in a solution with a pH higher than 4.5, paliperidone will tend to be in its ionized form, while in a solution with a pH lower than 4.5, it will tend to be in its non-ionized form.
How can you calculate pka valve if pH is given?
You can calculate the pKa value by using the Henderson-Hasselbalch equation: pH = pKa + log([A-]/[HA]), where [A-] is the concentration of the conjugate base and [HA] is the concentration of the acid. Rearranging the equation, you can solve for pKa by taking the antilog of both sides after isolating pKa.
What would be the pH at the half-equivalence point in titration of a monoprotic acid with NaOH solution if the acid has Ka equals 5.2x10-6?
At the half-equivalence point, the moles of acid initially present are equal to the moles of base added. This corresponds to half the acid being neutralized, forming a buffer solution. The pH can be calculated using the Henderson-Hasselbalch equation: pH = pKa + log([A-]/[HA]), where [A-] is the concentration of the conjugate base and [HA] is the concentration of the acid.
What does pH of a solution depend on?
The molarity. The hydrogen ion concentration. If given the Ka just use the Henderson-Hasselbach equation pH=pKa+log(base/acid)
What does pH of the solution depend on?
The molarity. The hydrogen ion concentration. If given the Ka just use the Henderson-Hasselbach equation pH=pKa+log(base/acid)
What is the pka of .012M solution and a pH of 2.31?
HA ==> H+ + A-Ka = [H+][A-][HA] and from pH = 2.31, calculated [H+] = 4.89x10^-3 M Ka = (4.89x10^-3)(4.89x10^-3)/0.012 Ka = 1.99x10^-3 pKa = 2.70
How do you get pKa with the pH of a solution?
To calculate pKa from the pH of a solution, use the formula: pKa = -log(Ka) where Ka is the acid dissociation constant. If you know the pH of the solution and the concentration of the acid, you can also use the Henderson-Hasselbalch equation: pH = pKa + log([A-]/[HA]), where [A-] is the concentration of the conjugate base and [HA] is the concentration of the acid.
What is definition of pka value and difference between pH and pKa?
The pKa value is a measure of the acidity or basicity of a molecule. It represents the pH at which the molecule is 50% dissociated. pH measures the concentration of hydrogen ions in a solution, while pKa is a specific value for a particular molecule that indicates its tendency to donate or accept protons.
The pH of ethanol?
the pH of ethanol can be calculated using its pKa value (pKa 15.9) and the Henderson-Hasselbalch equation. pH = pKa - log [AH/A] where [AH/A] the ratio of disassociated versus undisassociated species in solution.
What pH of pka is 5.4?
A pH of 5.4 corresponds to a pKa of 5.4. This means that at a pH of 5.4, the concentration of the protonated and deprotonated forms of the molecule will be equal, making it an effective buffer at this pH.
What is Henderson-Hasselbalch equation?
Its an equation you can use to find the pH of a solution. it is.... --- pH = pKa + log (Base/Acid) --- these may help too Ka = 10^-pKa Kw = Ka*Kb
Effect of Diluting a buffer?
The buffer capacity increases as the concentration of the buffer solution increases and is a maximum when the pH is equal to the same value as the pKa of the weak acid in the buffer. A buffer solution is a good buffer in the pH range that is + or - 1 pH unit of the pKa. Beyond that, buffering capacity is minimal.
Will the drug be ionized if it's pKa lower than the physiological pH and why?
Yes, if a drug's pKa is lower than the physiological pH, it will be largely ionized in the body. This is because at a pH above its pKa, the drug will exist in its ionized form.
What is the pH of a 0.05M solution of TRIS acid with a pKa of 8.3?
The pH of a solution of TRIS acid can be calculated using the Henderson-Hasselbalch equation: pH = pKa + log([A-]/[HA]). For TRIS with a pKa of 8.3, at a concentration of 0.05M, the pH will be around 8.3 since the concentration of TRIS acid (HA) is equal to its conjugate base (A-).
What is the PH value of potassium sulphate?
The pH value of potassium sulfate, K2SO4, is neutral, around 7. This is because potassium sulfate dissociates in water to release potassium ions (K+) and sulfate ions (SO4^2-) which do not significantly affect the pH of the solution.
What is the relation between pH and pOH?
pH = pKa + log([A-]/[HA]) pH = pKa+log([conjugate base]/[undissociated acid]) The actual meaning of pKa: the negative log of the dissociation constant, which is a measure of strength of an acid/base when pKa = pH, there is equal concentration of acid and its conjugate base. pKa helps to understand the nature of acid and base like pH: pKa 2 but 7 but < 10 -- weak base pKa >10 --strong base
The acid base indicator bromcresol green is weak acid. The yellow acid and blue base forms of the indicator are present in equal concentrations in a sloution when the pH 4.68. What is b.g. pKa?
By definition, the pKa of a weak acid is the pH at which the concentrations of the acid and its conjugate base are equal. In this case, since the solution is yellow (acid) and blue (base) at pH 4.68, it means that the concentration of the acid and base forms of the indicator are equal. Therefore, the pKa of bromcresol green is 4.68.
