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Denervation hypersensitivity occurs in multiple sclerosis. In multiple sclerosis demyelination of oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system result in disruption of communication between upper motor neurons in the brain and the lower motor neurons in the gray matter of the spinal cord. The end result is denervation hypersensitivity with physical symptoms of increased muscle tone, difficulty controlling muscles, exaggerated reflexes, and muscle spasms.

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17y ago
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4mo ago

Denervation hypersensitivity is caused by an increase in the sensitivity of postsynaptic neurons to neurotransmitters due to the absence of inhibitory input from the presynaptic neuron. This can lead to an increased response to neurotransmitters and a lower threshold for firing action potentials in the postsynaptic neuron, resulting in a heightened sensitivity to stimuli.

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Q: What is the neuronal basis of denervation hypersensitivity?
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