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Bioavailability of a drug refers to the fraction of the administered dose that reaches systemic circulation in an unchanged form. It is a measure of the extent and rate at which the active ingredient is absorbed and becomes available at the site of action in the body. Bioavailability is influenced by factors such as route of administration, drug formulation, and first-pass metabolism.
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Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
No, a drug that is 100 percent absorbed from the gastrointestinal (GI) tract would not necessarily have 100 percent bioavailability. Bioavailability is affected by factors such as first-pass metabolism in the liver, which can reduce the amount of the drug that reaches the systemic circulation unchanged. Thus, even if a drug is fully absorbed, its bioavailability may be less than 100 percent.
How route of administration drug can control bioavailability drug?
The route of administration of a drug can affect its bioavailability by influencing factors such as first-pass metabolism, absorption rate, and drug stability. For example, intravenous administration bypasses the first-pass metabolism, leading to higher bioavailability compared to oral administration where the drug may be metabolized before reaching the systemic circulation. Additionally, different routes can also affect the onset of action and duration of drug effects.
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Chemical instability in the gastrointestinal tract can lead to degradation of the drug before absorption, reducing its bioavailability. Drugs that are unstable in the gastrointestinal environment may not reach systemic circulation in sufficient amounts to exert the desired therapeutic effect. Ensuring chemical stability in the gastrointestinal tract is important for maintaining the effectiveness of orally administered drugs.
What is mineral bioavailability?
Mineral bioavailability refers to the extent to which minerals from food are absorbed and utilized by the body. Factors such as the form of the mineral, interactions with other nutrients, and individual characteristics can influence bioavailability. High bioavailability ensures that the body can effectively benefit from the minerals consumed.
What is drug polymorphism?
Drug polymorphism refers to the ability of a pharmaceutical compound to exist in more than one crystalline form, each with distinct physical and chemical properties. This can impact the drug's solubility, stability, bioavailability, and ultimately its therapeutic effectiveness. Pharmaceutical companies must ensure consistent quality and performance of the drug product, despite potential polymorphism variation.
What is bioavailability?
Bioavailability is the amount of drug which reaches the site of physiological activity after administration.
What is a bioequivalence?
A bioequivalent is a formulation of a drug which is equivalent to some other formulation in terms of bioavailability.
Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
No, a drug that is 100 percent absorbed from the gastrointestinal (GI) tract would not necessarily have 100 percent bioavailability. Bioavailability is affected by factors such as first-pass metabolism in the liver, which can reduce the amount of the drug that reaches the systemic circulation unchanged. Thus, even if a drug is fully absorbed, its bioavailability may be less than 100 percent.
Bio availabilty has a better feature when it gets dissolved or undissolved?
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html
How route of administration drug can control bioavailability drug?
The route of administration of a drug can affect its bioavailability by influencing factors such as first-pass metabolism, absorption rate, and drug stability. For example, intravenous administration bypasses the first-pass metabolism, leading to higher bioavailability compared to oral administration where the drug may be metabolized before reaching the systemic circulation. Additionally, different routes can also affect the onset of action and duration of drug effects.
What is a bioenhancer?
A bioenhancer is a biological enhancer - any naturally-occurring compound which increases drug bioavailability.
What is the medical term meaning extent to which a drug or other substance becomes available to the body?
Bioavailability
What is bioenhancer?
A bioenhancer is a biological enhancer - any naturally-occurring compound which increases drug bioavailability.
What factors determine a drug's rate of metabolism?
How quickly a drug clears from the body is a function of its absorption, bioavailability, distribution, metabolism, and excretion properties.
Why is a pharmaceutical equivalent not necessarily therapeutically equivalent?
They can still have different bioavailability (the amount of drug that is delivered to the site of action and the rate at whcih it is available). Pharmacetical equivalents do not have to have the same release mechanisms, and can therefore affect their bioavailability.
What is bioavilability in pharmacology?
Bioavailability in pharmacology refers to the fraction of a drug that reaches the systemic circulation and is available to produce an effect after administration. It is typically expressed as a percentage and takes into account how much of the administered dose is absorbed and becomes available to the body. Factors like drug formulation, route of administration, and first-pass metabolism can affect a drug's bioavailability.
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Chemical instability in the gastrointestinal tract can lead to degradation of the drug before absorption, reducing its bioavailability. Drugs that are unstable in the gastrointestinal environment may not reach systemic circulation in sufficient amounts to exert the desired therapeutic effect. Ensuring chemical stability in the gastrointestinal tract is important for maintaining the effectiveness of orally administered drugs.
