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Proton pump inhibitors may increase the pH of the stomach. This will inactivate some antifungal drugs that require an acid medium for effectiveness, notable itraconazole and ketoconazole.

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Proton pump inhibitors (PPIs) can interact with other medications, affecting their absorption and metabolism. Common interactions include reduced effectiveness of clopidogrel, increased risk of hypomagnesemia with diuretics, and increased levels of certain drugs metabolized by the liver due to PPI effects on liver enzymes. It is important to consult a healthcare provider before starting or stopping any medications while taking PPIs.

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9mo ago
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Q: What interactions are possible with proton pump inhibitors?
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