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Metachromatic leukodystrophy is a rare genetic disorder that affects the central nervous system, leading to the breakdown of myelin. Symptoms may include muscle weakness, cognitive decline, and vision and hearing loss. Without treatment, it can result in severe disability and premature death.
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What types of professionals are involved in the treatment of metachromatic leukodystrophy?
Professionals involved in the treatment of metachromatic leukodystrophy typically include neurologists, genetic counselors, physical therapists, occupational therapists, speech therapists, and social workers. A multidisciplinary approach is often used to address the various symptoms and complications associated with the disease. In some cases, palliative care specialists may also be involved to help manage symptoms and provide support for patients and families.
Example of bacteria for metachromatic granules?
Corynebacterium diphtheriae is an example of a bacterium that contains metachromatic granules. These granules are composed of polyphosphate polymers and are typically observed in the metachromatic staining method where the granules appear blue or purple when stained with methylene blue.
What is the principle of metachromatic granule staining?
Metachromatic granule staining is based on the principle that certain dyes can bind to specific cellular structures within bacterial cells, causing them to appear a different color than the rest of the cell. This staining technique is commonly used in microbiology to differentiate between different types of bacteria based on their internal structures.
What are the possible future effects of the problem?
The possible future effects of a problem can vary depending on the specific issue. Common effects can include increased costs, reduced efficiency, damaged reputation, and potential regulatory/legal consequences. Addressing the problem promptly and effectively can help mitigate these future effects.
What three noteworthy physical characteristics of Corynebacterium diphtheriae are visible after performing a simple stain?
After performing a simple stain, three noteworthy physical characteristics of Corynebacterium diphtheriae visible under the microscope are: rod-shaped morphology, irregular clumping arrangement (palisade arrangement), and metachromatic granules (babes-Ernst granules).
What are the characteristics of the juvenile form of metachromatic leukodystrophy?
The juvenile form of metachromatic leukodystrophy is characterized by gait disturbances, urinary incontinence, mental deterioration, and emotional difficulties
What is metachromatic leukodystrophy?
Metachromatic leukodystrophy (MLD) is a rare degenerative neurological disease affecting the fatty covering that acts as an insulator around nerve fibers known as the myelin sheath.
What do people with Metachromatic Leukodystrophy die from?
Liver and kidney falure.
What are the characteristics of adult metachromatic leukodystrophy?
Adult metachromatic leukodystrophy is characterized by emotional disturbances and psychiatric symptoms. Disorders of movement and posture appear later. Dementia and decreased visual function also occur.
What kind of inherited condition is Metachromatic leukodystrophy?
Metachromatic leukodystrophy (MLD), also called sulfatide lipidosis and arylsulfatase A (ARSA) deficiency, is inherited as an autosomal recessive trait, due to mutations in the arylsulfatase A (ARSA) gene
Whatv types of Leukodystrophy are seen in certain ethnic groups?
Canavan disease in Ashkenazi Jews, or globoid cell leukodystrophy (GLD) and metachromatic leukodystrophy (MLD) in Scandinavians.
What rehabilitation do metachromatic leukodystrophy patients undergo?
Physical therapists, occupational therapists, orthopedists, ophthalmologists, and neuropsychologists are often involved in helping maintain optimal function for as long as possible.
What is the prognosis for children with the late infantile form of metachromatic leukodystrophy?
Death usually results within five years after the onset of clinical symptoms
What are the symptoms of infantile metachromatic leukodystrophy?
The infant displays irritability and an unstable walk. As the disease progresses, physical and mental deterioration occur and muscle wasting eventually gives way to spastic movements
What is the treatment for metachromatic leukodystrophy?
In infants neurocognitive function may be stabilized, while persons with the juvenile and adult forms of MLD and with mild symptoms are more likely to be stabilized with bone marrow transplantation
How does metachromatic leukodystrophy affect a human organism?
Sulfatide accumulates in the brain and other areas of the body such as the liver, gall bladder, kidneys, and/or spleen. The buildup of sulfatide in the central nervous system causes demyelination
What are the symptoms of Metachromatic leukodystrophy?
the primary early symptoms are speech difficulties, gait disturbance, behavioral problems, and intellectual decline. The disease progresses rapidly; seizures, blindness, and severe muscle contractions may occur
