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Hemophilia itself is really just a genetic disorder. It causes problems with blood coagulation and people with the disorder tend to bleed a lot if cut, hence the name "bleeders." The disorder is caused by a mutation in the factor VIII gene, leading to a deficiency in factor VIII. (Factor VIII is a protein that is associated with blood clotting.) The deficiency in the blood clotting factor causes the affected person's blood to clot improperly. The factor VIII gene is located on the X-chromosome and is transmitted by recessive inheritance. Males have an X-chromosome and and a Y-chromosome and females have two X-chromosomes. This means that females would only carry one of the mutant alleles for hemophilia and are said to be carriers. Females are usually found to be only carriers and rarely express hemophilia. Males, on the other hand, will receive one X-chromosome from their mother and a Y-chromosome from their father, leading to hemophilia.
Hemophilia is primarily caused by a change in a specific gene located on the X chromosome. People with hemophilia have mutations in the genes that encode for clotting factors, leading to difficulties in blood clotting. Changes in chromosomes can also play a role in some cases, such as large deletions or rearrangements involving the genes responsible for clotting factors.
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If you know a woman has hemophilia what can you infer about her parents genetype?
If a woman has hemophilia, it means she inherited one affected X chromosome from each of her parents. This suggests that her father is likely a carrier of the hemophilia gene on his X chromosome, and her mother is either a carrier of the gene on one of her X chromosomes or has hemophilia herself.
What is a carrier for hemophilia?
A carrier for hemophilia is a female who carries the genetic mutation for hemophilia on one of her X chromosomes, but does not exhibit symptoms of the condition herself. Carriers can pass on the gene mutation to their children, resulting in hemophilia in male offspring. Testing can confirm carrier status.
Does hemophilia result from too many or too few chromosomes?
The gene for the most well known form of hemophilia is located on the X chromosome. It is not the result of too many or too few chromosomes. A male receives only one X chromosome while the receives two X chromosomes. These gene codes for factor VIII, one of the factors within the clotting cascade. If a female inherits the mutated gene, she has a second gene on the other X chromosome. However, she is capable of passing the gene for hemophilia onto her children. Males inherit one X chromosome and so have hemophilia. This is for informational purposes only and should not be construed as a complete answer.
Why is hemophilia rarely expressed in females?
Hemophilia is a genetic disorder that is X-linked, meaning it is carried on the X chromosome. Females have two X chromosomes, so even if one carries the gene for hemophilia, the other X chromosome can usually compensate for it. In males, who only have one X chromosome, the gene for hemophilia is more likely to be expressed.
Can a male be a carrier for hemophilia?
Yes, males can be carriers for hemophilia. While hemophilia is more common in males, as it is an X-linked genetic disorder, females can also carry the gene and pass it on to their children. Males who inherit the gene will have hemophilia, while females who inherit the gene can be carriers and potentially pass it on to their children.
What chromosomes has been determined to carry this gene in hemophilia?
the X chromosome
Why Hemophilia more common in male than in female?
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
If you know a woman has hemophilia what can you infer about her parents genetype?
If a woman has hemophilia, it means she inherited one affected X chromosome from each of her parents. This suggests that her father is likely a carrier of the hemophilia gene on his X chromosome, and her mother is either a carrier of the gene on one of her X chromosomes or has hemophilia herself.
What do you get when you cross a male hemophiliac with a female hemophiliac?
The gene for hemophilia A is found on the X chromosome (it is a sex-linked recessive disorder). Women have two X chromosomes and men have one X chromosome. A woman with hemophilia (very rare) would have the mutated gene on both of her X chromosomes. This means that all of their children, both male and female would have hemophilia.
Which chromosome contains the gene for hemophilia?
The X chromosome. That's why it's more common in males; females have 2 X chromosomes, but males only have 1. So if a woman has the hemophilia mutation on one of her chromosomes, she probably won't be affected by it.
Explain why a woman carrying a gene for hemophlia can produce hemophilic sons when she is mated with a normal male?
A woman carrying a gene for hemophilia can produce hemophilic sons because hemophilia is a recessive genetic disorder located on the X chromosome. Females have two X chromosomes, so if one carries the hemophilia gene and the other is normal, she is a carrier. When she mates with a normal male who carries a Y chromosome, there is a 25% chance that she will pass on the X chromosome with the hemophilia gene to her son, resulting in him being hemophilic.
What do you call a change in a gene or chromosomes?
mutation
What is a carrier for hemophilia?
A carrier for hemophilia is a female who carries the genetic mutation for hemophilia on one of her X chromosomes, but does not exhibit symptoms of the condition herself. Carriers can pass on the gene mutation to their children, resulting in hemophilia in male offspring. Testing can confirm carrier status.
Why is hemophilia more common in males than in females?
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
Does hemophilia result from too many or too few chromosomes?
The gene for the most well known form of hemophilia is located on the X chromosome. It is not the result of too many or too few chromosomes. A male receives only one X chromosome while the receives two X chromosomes. These gene codes for factor VIII, one of the factors within the clotting cascade. If a female inherits the mutated gene, she has a second gene on the other X chromosome. However, she is capable of passing the gene for hemophilia onto her children. Males inherit one X chromosome and so have hemophilia. This is for informational purposes only and should not be construed as a complete answer.
Why is hemophilia rarely expressed in females?
Hemophilia is a genetic disorder that is X-linked, meaning it is carried on the X chromosome. Females have two X chromosomes, so even if one carries the gene for hemophilia, the other X chromosome can usually compensate for it. In males, who only have one X chromosome, the gene for hemophilia is more likely to be expressed.
Why are women carriers for the disease hemophilia?
Women can, in fact, suffer from haemophilia, but it is more rare in women, as it is a recessive, sex-linked X chromosome disorder, so in order to manifest the disease, a woman would need two copies of the defective gene, while men need only one. Thus it is guaranteed to manifest in a man who carries the gene, but not in a woman unless she receives the gene from both parents.
