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How can mutation in single DNA base affect the production of normal proteins?
Wiki User
∙ 12y ago
mutation in a single DNA base may have no effect on the phenotype or may have a great effect. the best example on this is sickle cell anaemia.
haemoglobin is formed of 2 alpha chains of protein and 2 beta chains, this is the beginning of the a.a sequence of beta chains: val-his-leu-thr-pro-glu-glu-lys
in some people, the mutation causes the substitution of a single thymine base with adenine. this causes one of the glutamine molecules with valine so the chain is this:
val-his-leu-thr-pro-val-glu-lys .
this very slight change causes the blood to form fibrous structures when it's not combined with oxygen. this causes many rbcs to be useless at transporting oxygen and the fibers may get stuck in capillaries which will prevent unaffected cells from getting through.
Wiki User
∙ 12y ago
A mutation in a single DNA base can lead to a different amino acid being incorporated into the protein during translation, causing a change in the protein's structure and function. This alteration can disrupt the normal folding or activity of the protein, impacting its ability to carry out its biological role effectively.
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WhIch best describes the initial change cause by a DNA mutation?
A DNA mutation can lead to changes in the sequence of nucleotides in the DNA, which can alter the instructions for building proteins. These changes can result in the production of a faulty protein or a non-functional protein, which can affect the normal functioning of cells and potentially lead to disease or other conditions.
What is a mutation disease?
A mutation disease is a disorder caused by a genetic mutation, which is an alteration in the DNA sequence. These mutations can lead to changes in the structure or function of proteins, affecting normal biological processes and potentially causing disease. Examples of mutation diseases include cystic fibrosis and sickle cell anemia.
How can mutation in DNA disrupt proper functioning?
A mutation in a gene can change the amino acid sequence of the protein the gene makes. These alterations in the proteins' primary structure may affect the secondary, tertiary, and quaternary structure, all which have to be exact for proper functioning. The mutation in a gene can also put a STOP message in the sequence so the protein is terminated prematurely, leading to a truncated polypeptide. Some polypeptides simply won't work, and when critical proteins are not functioning, the cell can cease to run metabolic reactions or undergo mitosis. Other polypeptides will become deleterious and directly harm the cell.
What is dominant negative mutation?
A dominant negative mutation occurs when a mutant protein interferes with the function of the normal protein produced by the other allele, resulting in a loss of function phenotype. This typically happens in genes that encode multimeric proteins where the mutant protein can disrupt the function of the wild-type protein.
A mutation is harmful to an organism if?
A mutation is harmful to an organism if it disrupts the normal functioning of essential genes or proteins, leading to abnormalities or diseases that decrease the organism's fitness or survival.
When when a mutation results in no significant change in the production of a of a functional protein?
When a mutation does not change the result of a normal production of a protein is called harmless. This is because it does no harm to the individual.
Will cells with mutations always make normal proteins?
Cells with mutations may not always produce normal proteins. Mutations can alter the DNA sequence, which may result in changes to the structure or function of the protein produced. These changes can lead to abnormal protein function, which can impact cellular processes and potentially contribute to disease.
What will mutation do if it does not occur in sex cells?
If a mutation occurs in non-sex cells, it will not be passed on to offspring because it is not present in the germ cells. Instead, the mutation will only affect the individual in which it occurs.
What is normal mutation?
Normal mutation refers to the spontaneous changes in the genetic material of an organism that occur naturally during cell division and reproduction. These mutations can lead to genetic diversity within a population and are essential for evolution and adaptation to changing environments.
What is a mutation disease?
A mutation disease is a disorder caused by a genetic mutation, which is an alteration in the DNA sequence. These mutations can lead to changes in the structure or function of proteins, affecting normal biological processes and potentially causing disease. Examples of mutation diseases include cystic fibrosis and sickle cell anemia.
A new mutation in mice cause the coast to be twice as normal In what environment would this mutation be helpful why?
New mutation in mice causes the coast to be normal in today's world. This is a well ask question.
How might normal variations in your genes affect your response to different medicines?
Normal variations in genes can impact how a person metabolizes medications, affecting their efficacy, dosage requirements, and potential side effects. Variations in genes encoding drug-metabolizing enzymes can lead to variations in drug metabolism rates, influencing how quickly a drug is broken down or eliminated from the body. Additionally, genetic variations can also affect drug targets or receptors, influencing a person's response to a medication.
Should you have Cancer?
No, Cancer is a mutation. It is not normal.
How can mutation in DNA disrupt proper functioning?
A mutation in a gene can change the amino acid sequence of the protein the gene makes. These alterations in the proteins' primary structure may affect the secondary, tertiary, and quaternary structure, all which have to be exact for proper functioning. The mutation in a gene can also put a STOP message in the sequence so the protein is terminated prematurely, leading to a truncated polypeptide. Some polypeptides simply won't work, and when critical proteins are not functioning, the cell can cease to run metabolic reactions or undergo mitosis. Other polypeptides will become deleterious and directly harm the cell.
What is dominant negative mutation?
A dominant negative mutation occurs when a mutant protein interferes with the function of the normal protein produced by the other allele, resulting in a loss of function phenotype. This typically happens in genes that encode multimeric proteins where the mutant protein can disrupt the function of the wild-type protein.
A mutation is harmful to an organism if?
A mutation is harmful to an organism if it disrupts the normal functioning of essential genes or proteins, leading to abnormalities or diseases that decrease the organism's fitness or survival.
What does the mutation rule state?
The mutation rule states that the state of mutations are in a mutated state when compared to a normal state. This is a slight mutation from the original stated rule.
