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The detector is very sensitive towards organic molecules (10-12 g/s, linear range: 106 -107), but relative insensitive to a few small molecules e.g. N2, NOx, H2S, CO, CO2, H2O. If proper amounts of hydrogen/air are mixed, the combustion does not afford any ions. If other components are introduced that contain carbon atoms cations are produced in the effluent stream. The more carbon atoms are in the molecule, the more fragments are formed and the more sensitive the detector is for this compound (-- > response factor). However, due to the fact that the sample is burnt (pyrolysis), this technique is not suitable for preparative GC. In addition, several gases are usually required to operate a FID: hydrogen, oxygen (compressed air), and carrier gas.Many GC instruments are coupled with a mass spectrometer, which is a very good combination. The GC separates the compounds from each other, while the mass spectrometer helps to identify them based on their fragmentation pattern.

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βˆ™ 6mo ago

The GC-MS detector is a mass spectrometer that can identify and quantify individual compounds in a sample based on their mass-to-charge ratio, providing a high level of specificity. On the other hand, the FID (Flame Ionization Detector) is a selective detector that measures carbon content in organic compounds based on the ionization of hydrocarbons by a hydrogen-air flame, offering high sensitivity and wide linear range. GC-MS is more suitable for identifying unknown compounds, while FID is better for detecting hydrocarbons and compounds containing carbon.

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Q: Compare between GC ms detector and fid?
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A qualitative and a quantitative result can be used to identify the co-elution in GC-MS.


Why volatile compounds are analysed in gc but not in hplc?

GC can give very resolved sharp peaks with short run time compared to hplc. additionally, there is less compatibility issue in setting an MS up to a GC than HPLC


Can GC and HPLC instruments be used in same room?

Yes, GC (Gas Chromatography) and HPLC (High Performance Liquid Chromatography) instruments can be used in the same room, as long as certain precautions are taken to prevent interference between the two instruments. This includes proper ventilation to avoid cross-contamination, proper spacing between the instruments to prevent vibrations or electromagnetic interference, and ensuring that the room meets the specific requirements for each instrument.


What is gas chromatograohy?

Gas chromatography (GC), is a common type of chromatography used in analytical chemistry for separating and analysing compounds that can bevaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.


What data does gas chromatography provide?

Gas chromatography (GC) provides data on the chemical composition of a sample. It separates and analyzes the individual components of a mixture based on their physical and chemical properties. The data provided by GC includes: Retention time: The time it takes for a compound to travel through the GC column and reach the detector. This can be used to identify the compound. Peak area: The area under the peak on the chromatogram represents the amount of the compound present in the sample. Peak height: The height of the peak on the chromatogram represents the concentration of the compound in the sample. Mass spectrum: GC can be coupled with mass spectrometry (GC-MS) to provide additional data on the molecular weight and structure of the compounds in the sample. Identification: GC can be used to identify individual compounds in a mixture based on their retention time and mass spectrum. This information can be compared to a database of known compounds to identify the unknown compounds in the sample.

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