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The quotation comes from fictional detective Sherlock Holmes, which makes the meaning easier to understand.
Sherlock always solves the mystery by deducing crucial information from minor details. Other people gloss over the minor details, thinking that they're unimportant, but to Sherlock every detail matters and every piece of information is important. Someone who isn't as smart as Sherlock wouldn't know how important the little things are, but to someone as smart as him there isn't anything that's not worth knowing, no matter how small it is.
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