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Botulinum toxin prevents the release of acetylcholine at the neuromuscular junction, leading to muscle weakness and paralysis. Improperly canned food can provide an environment for the growth of Clostridium botulinum bacteria, which produce this toxin. Ingestion of this toxin can result in botulism, a potentially life-threatening condition.
Botulinum toxin (aka. Botox, produced by the bacteria Clostridium Botulinum) causes paralysis by disrupting exocytosis of acetylcholine into the neuromuscular junction. When a nerve impulse reaches the neuromuscular junction, it normally triggers vesicles storing acetylcholine to fuse with the axonal membrane, releasing its contents into the junction where acetylcholine can trigger an action potential in the muscle fibre. Failure of the vesicle to fuse and release its contents into the junction deprives the muscle of any kind of signal that would cause contraction, thereby paralyzing it.
Well of course they meet at the neuromuscular junction
This point is often called the neuromuscular junction or motor end plate. ?The neurotransmitter used here is acetylcholine.Many diseases occur with dysfunction at this junction, like Myesthenia Gravis, botulism, or Lambert Eaton Myasthenic Syndrome.
ACh is not degraded, therefore, prolonged depolorization is enforced on the post synaptic memebrane
The junction between a motor neruon's axon and the muscle cell membrane is called a neuromuscular junction or a myoneuraljunction?
Ach (acetylcholine) is a neurotransmitter that is released by motor neurons at the neuromuscular junction. It binds to receptors on muscle cells, leading to muscle contraction.
ACETYLCHOLINE
The nervous system and the muscular system are connected by the neuromuscular junction. The connection is done with synapses between nerve and muscle fibers.
Neuromuscular Junction
neuromuscular junction
An axon and the sarcolemma.