The abbreviation becomes plural - Drs. Smith and Jones.
Do you mean something like "Drs. John and Martha Smith"?
To address multiple doctors, simply pluralize the abbreviation for doctor. For example, you would write "Dear Drs. John, Bob, and Sara".
If two married doctors have the same last name, they should be addressed as Drs. Last Name. If they have different last names, address them as Drs. Name 1 and Name 2.
If you are giving both first names, you should use separate titles, e.g. "Dr. Pierre and Dr. Marie Curie" Please note that f.i. in Dutch Drs is a completely different title from Dr (Drs being a Masters degree, Dr being either a doctorate or a medical title).
The salutation used for the envelope address can be either Dr. John Smith and Dr. Jane Smith, or Drs. John and Jane Smith. If you are writing a letter to both doctors, then he greeting in your letter can be Dear Drs. Smith.
Since both are doctors (medical and dental): If they use the same surname: Drs. Jones If they use different names: Drs, Jones and Smith.
If you are addressing a married couple who are both doctors you can address them two ways. You can address them by either stating Drs. Jack and Jill Smith or Dr. Jack Smith and Dr. Jill Smith.
Drs Name and Name e.g Drs Smith and Smith
IF the doctors both have the same last name you, use Drs. Smith or Drs. Jones.Addressing two or more doctors with different last names, use Dr. A. Smith and Dr B. Jones.
Drs. John and Mary Smith or if different last names Drs. John Smith and Mary Jones
All the DRS systems are the same but RBR seems to be able to use them more.