Mr. and Mrs. James Bitner III
Mr. and Mrs. John Smith III
Mr. and Mrs. David Mielke III
Mrs. Greta & Mr. Neal Featherston, Jr.
mr ans miss or.... for mrs is madame. mr ans miss or.... for mrs is madame.
I would address it to Mr and Mrs David Keys. For the salutation I would use Dear Mr and Mrs Keys.
As Mr & Mrs.
Mr. used to be acceptable to address a household by just using the last name, e.g. "Mr. Jones". In modern times, it is typically to use "Mr. and Mrs. Jones" or "Mr. and Mrs. Timothy Jones".
The proper way to address that letter would be "Mr. and Mrs. John Doe."
You can address it to Mr and Mrs. Smith. You could address it is as the Smith Family. Or you could address it as Mr. Smith and Family.
Mr. & Mrs. <lastname>
Whatever your address is!Sorry if there are any kids our there!