Anorexia (not eating or eating very little) is extremely serious and requires veterinary diagnosis and treatment. A cavy you have just brought home that is not eating may have a respiratory or other bacterial infection.
If your guinea pig has Anorexia, go to the vet immediately.
For more information and symptoms of Anorexia go to: http://www.guinealynx.info/anorexia.html
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A guinea pig may lose its appetite because it is sick or unwell. If you think so, then take your guinea pig to the vet immediately.