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This question has been the subject of study by many biologists. Research in this field, however, has been reduced to mostly theoretical, because of the ethical issues involved. Therefore, theoretically, it may be said that yes, it is likely that a cross-bred human and ape combination is possible. Almost all chromosomes between humans and other apes are identical. The other apes have one fewer chromosome pair, because their 2 and 4 chromosomes fused into a single, large one. However, an offspring could still be produced, with chromosomal polymorphism. Humans would probably be most compatible with either Bonobos or Chimpanzees, our closest living relatives, with whom we share 98% of our genome (this means that 98% of human DNA and Pan DNA is identical). As of yet, no recognized cross-breed has been produced.

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Q: Is it possible to cross bread a human to an ape?
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