Where the comma will eliminate any ambiguity in the sentence's interpretation.
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A comma is typically needed before a coordinating conjunction joining two independent clauses or to separate items in a list. It is also used after introductory phrases or clauses at the beginning of a sentence.
No, a comma is not needed after "yes" when starting a sentence.
When a sentence includes an extra phrase beginning with the word "that," a comma is typically not needed. The phrase acts as an essential part of the sentence's structure and does not require a comma to set it off.
No, a comma is not needed before and after the word "again" if it is in the middle of a sentence.
No, typically a comma is not needed after "otherwise" at the beginning of a sentence. It is not a coordinating conjunction that requires a comma to separate independent clauses.
You do not need a comma before "as needed" or "as directed." These phrases are typically used as adverbial phrases in a sentence and do not require a comma to separate them from the rest of the sentence.