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Yes, technically.

Sulfonamide is a chemical moiety (component of a molecule) from which sulfa antibiotics (most commonly in the US Bactrim/ Septra/ trimethoprim-sulfamethixizole) take their name. Allergies to it are common and people allergic to one sulfa antibiotic should not take others.

Other drugs such as Hydrochlorothiazide, furosemide, sulfonylurea Diabetes medications, Celebrex (pain med) and sumatriptan (Imitrex for migraines) also contain sulfonamides but they are chemically different and usually do not cross react in people allergic to sulfa antibiotics.

Whether people allergic to sulfa antibiotics should avoid these other drugs is controversial. Many references recommend it based on the chemistry but the fact is that cross reactions are very rare and so many experts believe that it is safe for them to be taken. Some recommend taking the first dose in the doctor's office.

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Q: Does hydrochlorothiazide contain sulfa
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