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Why you do friability test for tablet?
bcoz of coating. And for transport
What is A Film-coated Tablet?
This is the most extensively used tablet coating technique in the pharmaceutical industry. It personifies the tablet with different dyes and helps to stabilize the chemical compound. The unpleasant smell and taste of the pill are also masked. The film coating technique includes placing film solutions on tablets through a sprayer. This procedure is done once with a polymer, plasticizer, solvent, and dye solution. The pills are sprayed and quickly dried in a rotating tablet pan. After drying, a thin coating of polymer is created around a tablet. The tablet can sometimes keep its color; however, this can be adjusted if the solution is mixed with various dyes. There are now numerous varieties of tablet coating machines on the market. The following are the three main categories. Standard Pan Perforated Pan Fluidized Bed Processor Film Coating Process A polymer is dissolved in a solvent as well as other materials such as plasticizers, dyes, and pigments and sprayed into the tablet coater. You must put the tablets periodically into the coating pan to conduct the film coating. Measure the distance between the spray nozzle and tablet bed precisely and appropriate adjustments for even layering over the bed. The coating solution may normally atomize to very thin droplets. As the coating pan spins with the tablets, the sprayer will disperse the coating solution on the bed. Most of these devices include a multi-sprayer system. Droplets of the solvent hit the tablet and form a coating before the vapor is removed by hot air. This happens in a single-stage procedure, which retains a 2-3% rise in pill weight. The tablets are then dried to remove the solvent, resulting in a thin coating on each tablet known as a film.
Difference between film coating and enteric coating tablet?
Film coat is only coating that prevents the bitter taste while taking the medicinea nd protects the tablet from microbial growth. and color change. Enteric coat means (Enteric=Small intestine) this enteric coated tablet dissolved in only in small intestine. That means this type of coating prevents the drug release in other parts of the body. It will reacts with only small intestine fluids and get dissolved in 10mg concept. like 100mg tablet: 10mg>20mg>30mg>.......100mg complete dissolve.
Why are enteric coated tablets not crushed?
Because this would make the enteric coating coating useless and may upset the users stomach. An enteric coated tablet has a material that allows the tablet to pass through the stomach to the small intestine before the medication is released reducing the chance of stomach problems. Hope this helps. ~J
Whiskering occurs in tablet due to?
Whiskering in tablets occurs due to the separation of the film coating from the tablet core, leading to the formation of cracks or wrinkles that resemble whiskers. This can be caused by various factors such as moisture exposure, inadequate adhesion between the coating and core, or improper drying of the coating. Whiskering can affect the appearance and integrity of the tablet, potentially impacting its quality and stability.
What are the advantages and disadvantages of film coating?
Film coating is less time consuming than compression coating as less time is needed to dry the coat. As the coating is thin, its presence will not affect the tablet's weight that much. This method can also be used to create sustained release formulations. However, film coating is quite expensive due to the high cost of the coating material. The quality of the film also has to be monitored to ensure that they are continuous and uniformly thick.
What are the causes of dissolution of tablet?
This depends on the nature of tablet, temperature of water, stirring, crushing of the tablet to a fine powder, etc.
What is compression coating?
Compression coating involves compacting a granule around an already formed cored with compression equipment. Incompatible drugs can hence be combined together in one tablet. Sustained release drugs can also be produced. It is now rarely used today in the manufacturing industry as film coating is being used instead.
Can you coated a medicinal tablet by aluminium silicate?
Aluminum silicate is not typically used as a coating material for medicinal tablets because it does not provide a smooth or glossy finish, which is often desired for pharmaceutical tablets. Alternative coating materials such as cellulose derivatives, acrylic polymers, or shellac are commonly used for tablet coating due to their smooth and protective qualities.
What tablet size and liquid combination resulted in fastest dissolution time?
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Can 1000 mg depakote tablet be cut in half?
No, the tablets have a coating that controls the rate at which the drug is released and reduces the chance of stomach upset. Cutting the tablet can allow a very high initial dose that can have unpleasant results.
What are the different types of coatings on medicines?
Medicines either have no coating (example: Adult regular aspirin), or a jell-mixture that adheres to the powder and makes the tablet harder, or an enteric coating (a smoooth feeling shell that keeps the med from irritating the stomach). Other meds are powder placed inside a sealed capsule.
