The first computer made in Pa. was the Eniac at the University of Pa. The first microcomputers was the Altair, an early computer kit. The first commercial microcomputer was the Commodore Vic 20 manufactured at West Chester, Pa.
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Z3, an electromechanical programmable computer was invented in Berlin. ENIAC, the first general-purpose electronic computer was invented at the University of Pennsylvania.
as you are being so precise in your question, i can be very precise in my answer: ENIAC
The first desktop computer was probably the DEC PDP-8 minicomputer in 1965. It came in both desktop & rackmount versions. DEC was in Maynard, Massachusetts.
In the US, the first manufactured computer was the UNIVAC I in Philadelphia Pennsylvania by Remington Rand, in 1952.
ENIAC (Electronic Numerical Integrator And Computer)