How did the people react to the smallpox vaccine innovation?

Answer 1

His ideas were not accepted by everyone. Some of the medical profession refused to accept his results. There were problems and mistakes. Sometimes the vaccination was not done correctly. Sometimes the hospital mixed smallpox fluid with cowpox fluid. No one would publish his work. He did not have enough data to support his claims. Jenner had to pay for this to be done. Some even believed that they might turn into cows.

Answer 2

Very badly, most of them died and entire tribes and nations were wiped out.